Angiogenesis and tumor

Author(s):
Kamran  MansouriKamran Mansouri1,*, Ali MostafaieAli Mostafaie1, Hamid-Reza Mohammadi-MotlaghHamid-Reza Mohammadi-Motlagh1
1Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
*Corresponding Author: Corresponding author: Kamran Mansouri, Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran, Tel: +98 831 4276473 Email: [email protected]

Journal of Kermanshah University of Medical Sciences:Vol. 14, issue 4; e79444
Published online:Mar 19, 2011
Article type:Review Article
Received:Nov 24, 2009
Accepted:May 25, 2010
How to Cite:Mansouri K, Mostafaie A, Mohammadi-Motlagh H. Angiogenesis and tumor. J Kermanshah Univ Med Sci. 2011;14(4):e79444. doi:

Abstract

Angiogenesis, the process of new blood vessel formation from existing ones, plays an important role in  the physiologic circumstances such as embryonic development, placenta formation, and wound healing. It is also crucial to progress of pathogenic processes of a variety of disorders, including tumor growth and metastasis. In general, angiogenesis process is a multi-factorial and highly structured sequence of cellular events comprising migration, proliferation and differentiation of endothelial cells and finally vascular formation, maturation and remodeling.Thereby, angiogenesis inhibition as a helping agent to conventional therapies such as chemotherapy and radiation has attracted the scientists’ attentions studying in this field.

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© 2011, Journal of Kermanshah University of Medical Sciences. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.

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