Journal of Kermanshah University of Medical Sciences
Peer-reviewed Medical Quarterly
Outlines
Morphological changes in hippocampus CA1 neurons after nicotine administration in rats
Author(s):
1Dept. of Anatomy, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
2Applied Neuroscience Research Center, Baqyiatallah University of Medical Sciences, Tehran, Iran
*Corresponding Author: Corresponding author: Hedayat Sahraei, Applied Neuroscience Research Center, Baqyiatallah University of Medical Sciences, Tehran, Iran, E-mail: Email: [email protected]
Published online:Jun 19, 2009
Article type:Research Article
Received:Jan 13, 2009
Accepted:Mar 10, 2009
How to Cite:Jalili S, Sadeghi Y, Sahraei H. Morphological changes in hippocampus CA1 neurons after nicotine administration in rats. J Kermanshah Univ Med Sci. 2009;13(1):e79823. doi:
Abstract
Background: Previous studies have shown morphological changes after intra peritoneal drug administration in human and animals. This study examines the effect of intrapretoneal nicotine administration on pyramidal neurons in area CA1of hippocampus.
Methods: The study included male Wistar rats with the mean weigh of 220-250 g. Nicotine was administered at a dose of 0.4 and 1.5 mg/kg, each for a period of three days. The animals were then anesthetized using ketamine (70 mg/kg). After being fixed through transcardiac canula with formalin 4% and bafer phosphate 6, the brains were sectioned and stained using Golgi’s staining technique. Using MOTIC software, they were then examined for histological evaluations. Data were analyzed using unpaired ttest
Results: Our results showed a decrease in the size and the number of pyramidal cells in area CA1 of hippocampus for the nicotine group. While the number of dendrites was fewer in experimental group, asterocytes had increased in comparison to the control group.
Conclusion: Our study indicates that nicotine administration results in a significant reduction in the size of pyramidal cells in area CA1of hippocampus.
References
- 1.The references of this article is available on PDF.
Copyright
© 2009, Journal of Kermanshah University of Medical Sciences. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.
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