The Effect of Vitamin E Supplementation on Mild Hypertension

M Boshtam‎; M Rafiei; K Sadeghi; N Sarraf-Zadegan

Journal of Kermanshah University of Medical Sciences

Peer-reviewed Medical Quarterly

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The Effect of Vitamin E Supplementation on Mild Hypertension

Author(s):

M Boshtam‎^1,*,

M Rafiei²,

K Sadeghi²,

N Sarraf-Zadegan²

1Professor in Internal Medicine, Cardiovascular Research Center of Isfahan University of Medical Sciences‎, Iran

2Iran

Journal of Kermanshah University of Medical Sciences:Vol. 11, issue 1; e80904

Published online:Jun 20, 2007

Article type:Research Article

Received:Sep 03, 2005

Accepted:Nov 07, 2006

How to Cite:Boshtam‎ M, Rafiei M, Sadeghi K, Sarraf-Zadegan N. The Effect of Vitamin E Supplementation on Mild Hypertension. J Kermanshah Univ Med Sci. 2007;11(1):e80904. doi:

Abstract

Introduction: Hypertension as a major coronary artery disease (CAD) risk factor is more prevalent in Iran. In recent years, the effect of antioxidants in reducing CAD and their risk factors has been considered. Therefore, this triple blind placebo-controlled clinical trial was performed to determine the effects of antioxidant vitamin E on blood pressure in patients with mild hypertension.

Materials & Method: 70 subjects with mild hypertension (SBP: 140-160 mmHg, DBP: 90-100) and without secondary hypertension who were referred to hypertension unit in Isfahan Cardiovascular Research Center were recruited. All subjects were aged between 20 and 60 years old with only one cardiovascular risk factor. They were divided randomly into two sub-groups of supplement or placebo. Two sub-groups were matched for confounding factors such as job, age, sex, religion and education level. Supplement group was received 200 IU/day vitamin E tablet and placebo group was received a placebo tablet per day for 27 weeks. At the beginning and at the end of the study, the vitamin E level was measured using Hansen & Warwick method by flourometric method in all subjects. Blood pressure and heart rate were measured at the beginning; during and at the end of the study by a physician using the same sphygmomanometer.

Results: At the end of the study, it was found that the vitamin E supplement decreased 24% systolic blood pressure compare to 1.6% in placebo group (p<0.05. Diastolic blood pressure was decreased 12.5% in supplement and 6.2% in placebo group after 27 weeks (P<0.05).

Conclusion: It is concluded that 200 IU/day vitamin E supplement as decreases mild hypertension may be the cause of increasing long term availability of nitric oxide and its influences to monitor blood pressure.

Keywords

Vitamin E

Systolic Blood Pressure

Diastolic Blood Pressure

Mild Hypertension

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Modulation of Blood Pressure in Hypertensive Patients by Vitamin C

Mohammad Javad Zibaeenezhad,

Mohammad Hassan Eftekhari,

Kamran Aghasadeghi

Zibaeenezhad MJ, Eftekhari MH, Aghasadeghi K. Modulation of Blood Pressure in Hypertensive Patients by Vitamin C. Int Cardiovasc Res J. 2009;3(1):e68525. doi:

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Effect of vitamin C supplements on patients with hypertension

SH Ravanshad,

SH Sadeghi,

MJ . Zibaeinejad,

E Setoudeh Maram,

H Montaseri

Ravanshad S, Sadeghi S, . Zibaeinejad M, Setoudeh Maram E, Montaseri H. Effect of vitamin C supplements on patients with hypertension. J Inflamm Dis. 2024;9(2):e155133. doi:

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Vitamin D and Hypertension

Tina Jafari Jafari,

Zamzam Paknahad

Jafari TJ, Paknahad Z. Vitamin D and Hypertension. Zahedan J Res Med Sci. 2014;16(6):. doi:

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2021

Effect of vitamin D administration on blood oxidative stress factors in university students: A randomized double-blind clinical trial

Fatemeh Dabaghzadeh,

Maryam Rahimpour,

Somayyeh Karami-Mohajeri

Dabaghzadeh F, Rahimpour M, Karami-Mohajeri S. Effect of vitamin D administration on blood oxidative stress factors in university students: A randomized double-blind clinical trial. koomesh. 2021;23(6):e153304. doi:

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Effects of oral vitamin C supplement on the serum lipid profile

Mojgan Mohajeri-Iravani,

Ebrahim Hazrati,

Shahram Firuz-Marani Firuz-Marani

Mohajeri-Iravani M, Hazrati E, Firuz-Marani SF. Effects of oral vitamin C supplement on the serum lipid profile. Ann Mil Health Sci Res. 2015;13(1):e62671. doi:

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Author(s):

M Boshtam‎:[PubMed][Scholar]
M Rafiei:[PubMed][Scholar]
K Sadeghi:[PubMed][Scholar]
N Sarraf-Zadegan:[PubMed][Scholar]

Peer-reviewed Medical Quarterly

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The Effect of Vitamin E Supplementation on Mild Hypertension

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