Formulation and Evaluation of Langsat (Lansium domesticum Corr.) Peel Ethanol extracts Lotion as Anti-Mosquito Repellent

Author(s):
Rama HiolaRama Hiola1,*, Nurul RizkyNurul Rizky2, Hamsidar HasanHamsidar Hasan2, Nurain ThomasNurain Thomas2
1Department of Public Health, Faculty of Sport and Health, State University of Gorontalo, Indonesia
2Department of Pharmacy, Faculty of Sport and Health, State University of Gorontalo, Indonesia
*Corresponding Author: Corresponding author: Department of Public Health, Faculty of Sport and Health, State University of Gorontalo, Indonesia. Email:[email protected]

Journal of Reports in Pharmaceutical Sciences:Vol. 7, issue 3; 250-259
Published online:Jun 19, 2018
Article type:Research Article
Received:Apr 09, 2018
Accepted:Jun 08, 2018
How to Cite:Hiola R, Rizky N, Hasan H, Thomas N. Formulation and Evaluation of Langsat (Lansium domesticum Corr.) Peel Ethanol extracts Lotion as Anti-Mosquito Repellent. J Rep Pharm Sci. 2018;7(3):e147492. doi:

Abstract

The repellent is a material that works in protecting humans from mosquito bites. Langsat peel (Lansium domesticum Corr.) is one of the plants having function as repellent, anti-mosquito containing triterpenoid compound. The purpose of this research was to formulate the langsat peel ethanol extract into anti-mosquito lotion and to determine the effectiveness of repellent anti-mosquito from the best formulation of the langsat peel ethanol extract. The Optimization of the lotion basis was performed on three variations of cetyl alcohol concentrations i.e. 3%, 5%, and 7% respectively and obtained F2 containing 5% Cetyl alcohol as the optimum base. The F2 lotion basis formula was formulated into lotion with three concentrations of 10%, 20%, and 35%. The three lotions formula of the langsat peel ethanol extract was tested by organoleptic test, preparation, spreading test, adhesion test and stability test, including pH and viscosity exposed at 15-30oC, 4oC and 40oC. All formulas were tested for irritation using rabbits for 3 days and did not show any erythema and edema. Tests of the effectiveness of anti-mosquito were done on rabbit using mosquitoes. The results obtained showed that langsat peel extract 20% and 35% had effectiveness as anti-mosquito repellent and can be formulated into lotion dosage form.

Copyright

© 2018, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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