Journal of Reports in Pharmaceutical Sciences
Protective Effect Hydroalcoholic Extract Allium Jesdianum Boiss against Ccl4-Induced Hepatotoxicity in Male Mice
Heibatullah Kalantari1, 2, Esmat Keshavarzi2, Parvin Kheradmand3, Maedeh Goodarzian3, Leila Zeidooni
2, 4,*Abstract
Allium Jesdianum Boiss (Allium) has many pharmacological beneficial effects. However, its protective effects against hepatotoxicity induced by carbon tetrachloride (CCl4) have not been explained. The present study was undertaken to investigate the protective effects of Allium on liver oxidative stress in male mice treated to CCl4. Forty-two male mice were randomly divided into six groups. Control group, sham group, CCl4 group, Allium 500 mg/kg + CCl4, Allium 1000 mg/kg + CCl4, Allium 2000 mg/kg + CCl4. Results showed that CCl4 significantly increased serum levels of alanine aminotransferase, aspartate aminotransferase, lipid peroxidation and decreased catalase activity and glutathione level, and also caused inflammation, coagulative necrosis, degeneration of hepatocytes, fatty change, and dilated sinosouids in liver tissue. While administration of Allium at the all doses used significantly altered all examined endpoints that induced by CCl4. Overall, our findings suggest that Allium possesses hepatoprotective effects against CCl4-induced hepatotoxicity by suppressing oxidative stress and improving the antioxidative defense system.
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© 2018, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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