Journal of Semnan University of Medical Sciences
Effect of hydro-alcoholic extract of Vaccinium arctostaphylos on insulin release from rat-isolated langerhans islets
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Abstract
Introduction: Vaccinium arctostaphylos is one of the medicinal plants used in the treatment of diabetes. But the mechanisms responsible for its antidiabetic action have not been well defined. This study was undertaken to investigate the possible effect of V. arctostaphylos on insulin release from rat-isolated Langerhans islets. Materials and Methods : The islets were incubated in the presence of 3 or 10 mM glucose with or without milrinone (0.1 and 0.01%) and hydro-alcoholic extract of V. arctostaphylos (0.1 and 0.1%) for 60 min. The concentration of insulin was measured in samples of incubation medium. Results: The increase of glucose concentration in incubation medium from 3 to 10 mM resulted in a significant increase of insulin secretion. Milrinone at 0.1 mM significantly increased insulin release evoked by 10 mM glucose. However, none of the extract concentrations affected the insulin release. Conclusion: Our data demonstrated that V. arctostaphylos had no insulinotropic property and its effects on diabetes mediated by other mechanisms which should be clarified in future studies.
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© 2011, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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