Effect of alprazolam on analgesic action of ibuprofen in treatment of dysmenorrhea in 18-25 years old girls

 Introduction: Dysmenorrhea is one of the most common gynecologic complications in young women. Given the widespread use of ibuprofen in the treatment of dysmenorrhea, the purpose of present study was to determine the analgesic effect of ibuprofen by alprazolam in treatment of dysmenorrhea. Materials and Methods: The study was designed as a double blind clinical trial and cross-over study. 40 young female students with dysmenorrhea were randomly divided into two groups of 20. In the first month, the first 20 persons were received ibuprofen (400mg) every 8 hours and received placebo nightly from the time of menarche and the second group were received ibuprofen (400mg) every 8 hours and a single dose of alprazolam (0.5mg) every night for a period of 3 days. Then for the second month, the medicine regime was swiped between two groups. Data were collected using Cox menstrual symptom scale questionnaires.  Results: The mean scores of abdominal pain for the day 2 and 4 after treatment in ibuprofen-alprazolam group were lower than those one were observed for ibuprofen- placebo group ( both, P=0.000). Also, the mean scores of low back pain in both day 2 and 4 after treatment with ibuprofen-alprazolam group were significantly lower than those one were observed in the group, which was given ibuprofen- placebo (P=0.000, P=0.005, respectively). Conclusion: According to these findings, it might be proposed ibuprofen-alprazolam compound for relief of dysmenorrheal symptoms, which results in minimum adverse effects of pain on daily living activities as well as pain relief.