Comparison the protective effects of aqueous extract of Iranian propolis in 6-hydroxydopamine-induced model of parkinsonism in male rat with L-DOPA: A behavioral and histological evaluation

Manoochehr Safari; badban badban; Hamid Reza Sameni; Ahmad Reza Bandegi; ali rashidypour; Abbas Ali Vafaei

Koomesh

Journal of Semnan University of Medical Sciences

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Comparison the protective effects of aqueous extract of Iranian propolis in 6-hydroxydopamine-induced model of parkinsonism in male rat with L-DOPA: A behavioral and histological evaluation

Author(s):

Manoochehr Safari,

badban badban^,*,

Hamid Reza Sameni,

Ahmad Reza Bandegi,

ali rashidypour,

Abbas Ali Vafaei

Koomesh:Vol. 15, issue 4; 584-591

Published online:Sep 28, 2014

Article type:Research Article

Received:Sep 01, 2013

Accepted:Apr 01, 2014

How to Cite:Safari M, badban B, Sameni HR, Bandegi AR, rashidypour A, et al. Comparison the protective effects of aqueous extract of Iranian propolis in 6-hydroxydopamine-induced model of parkinsonism in male rat with L-DOPA: A behavioral and histological evaluation. koomesh. 2014;15(4):e152895. doi:

Abstract

Introduction: Parkinson´s disease(PD) is a common and progressive neuropathological disorder due to degeneration of neurodopaminergic system in substantianigra pars compacta. With regard to the role of free radicals and oxidative agents in PD, it seems that aqueous extract of propolis with antioxidant contents can prevent neural degeneration. In this study, neuroporotective effects of intrapritoneal(ip) injection of aqueous extract of Iranian propolis and L-DOPA were compared in an experimental model of PD. Materials and Methods: In this study, forty male rats were randomly divided into 8 groups: normal(N), lesioned(L), lesionedpropolis-treated 50,100mg/kg(L+propolis), lesioned L-DOPA-treated (L+LDOPA), propolis-pretreated and thenlesioned 50,100mg/kg(pretreatment+L) and sham-operated(SH) groups. The early PD model was induced by unilateral (left) intrastriatal injection of 6-hydroxydopamine (6-OHDA,4 µg/µl of saline-ascorbate). The pretreatment+L groups was received intra-peritoneal (ip) pretreatment of aqueous extract of Iranian propolis (AEP) (50,100mg/kg/daily) for 2 weeks before surgery. Two weeks after surgery, the treatment groups were received ip treatment of AEP(50,100 mg/kg/daily) and L-DOPA(10mg/kg/daily) respectively for two weeks. After two weeks treatment, the animals were tested for rotational behavior and the number of substantianigra pars compacta(SNC) neurons. Results: Our results showed that the aqueous extract of Iranian propolis decrease the rotational behavior in treatment and pretreatment rats and attenuate the reduction of number of SNC neurons. Conclusion: Our finding shows in experimental model of PD, intra-peritoneal administration of aqueous extract of Iranian propolis has remarkably protective effects against 6-OHDA toxicity

Keywords

Effect of potassium channel blocker 4-aminopyridine pretreatment on the 6-OHDA-induced Parkinson's disease in rats

M Sofiabadi,

hashem haghdoost-yazdi,

M Mahmudi,

H Pri,

T Dargahi,

M Yaghubidust

Sofiabadi M, haghdoost-yazdi H, Mahmudi M, Pri H, Dargahi T, et al. Effect of potassium channel blocker 4-aminopyridine pretreatment on the 6-OHDA-induced Parkinson's disease in rats. J Inflamm Dis. 2024;19(2):e155895. doi:

28

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Effects of hydroalcoholic extract of Iranian Propolis on blood serum biochemical factors in streptozotocin-induced diabetic rats

Hamid Reza Sameni,

Parisa Ramhormozi,

Ahmad Reza Bandegi,

AbbasAli Taherian,

Manochehr Safari,

Mohmmadhasan Tabriziamjad

Sameni HR, Ramhormozi P, Bandegi AR, Taherian A, Safari M, et al. Effects of hydroalcoholic extract of Iranian Propolis on blood serum biochemical factors in streptozotocin-induced diabetic rats. koomesh. 2014;15(3):e153882. doi:

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2016

Effect of potassium channel blocker of Tetraethylammonium pretreatment on prevention of the 6-OHDA-induced chronic Parkinson\'s disease in rats

Hashem Haghdoost-Yazdi,

Soheila sehat bakhsh,

Mohammad Sofiabadi,

Tahereh Dargahi,

MH Yaghubidust,

Hossein Piri

Haghdoost-Yazdi H, sehat bakhsh S, Sofiabadi M, Dargahi T, Yaghubidust M, et al. Effect of potassium channel blocker of Tetraethylammonium pretreatment on prevention of the 6-OHDA-induced chronic Parkinson\'s disease in rats. J Inflamm Dis. 2024;20(2):e155962. doi:

3

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2020

Effects of hydroalchoholic extract of Iranian Propolis on acute, chronic and visceral pain in mice

Abbasali Taherian,

Hamid Reza Sameni,

Shima Sharifi,

Mohammad Hossein Taherian

Taherian A, Sameni HR, Sharifi S, Taherian MH. Effects of hydroalchoholic extract of Iranian Propolis on acute, chronic and visceral pain in mice. koomesh. 2020;22(1):e153164. doi:

31

Oct

2015

Berberine chloride pretreatment exhibits neuroprotective effect against 6-hydroxydopamine-induced neuronal insult in rat

Feraidoon Negahdar,

Mehdi Mehdizadeh,

Mohammad Taghi Joghataei,

Mehrdad Roghani,

Fereshteh Mehraeen,

Ehsan Poorghayoomi

Negahdar F, Mehdizadeh M, Joghataei MT, Roghani M, Mehraeen F, et al. Berberine chloride pretreatment exhibits neuroprotective effect against 6-hydroxydopamine-induced neuronal insult in rat. Iran J Pharm Res. 2015;14(4):e125377. doi: https://doi.org/10.22037/ijpr.2015.1756

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Author(s):

Manoochehr Safari:[PubMed][Scholar]
badban badban:[PubMed][Scholar]
Hamid Reza Sameni:[PubMed][Scholar]
Ahmad Reza Bandegi:[PubMed][Scholar]
ali rashidypour:[PubMed][Scholar]
Abbas Ali Vafaei:[PubMed][Scholar]

Journal of Semnan University of Medical Sciences

Outlines

Comparison the protective effects of aqueous extract of Iranian propolis in 6-hydroxydopamine-induced model of parkinsonism in male rat with L-DOPA: A behavioral and histological evaluation

Abstract

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