Acceleration of skin wound healing in chronic diabetic rat by topical application of fish oil

Introduction: The benefit effects of fish oil has been reported on wound healing in acute diabetic rats. The fish oil contains omega-3 fatty acids, the aim of this study was to evaluate the effect of topical application of fish oil on wound healing in chronic diabetic rats, and this effect compared to corn oil effects. Material and Methods: This experimental study was performed on four groups of normal rats, Groups I (normal) consisted of normal rats, Group II (control), III (fish oil) and IV (corn oil) consisted of rats, which were became diabetic by streptozotocin (50 mglkg, S.C). Groups III, and IV received fish oil and corn oil respectively on all postoperative days . All animals were wounded by a vertical 4 em incision in the .midline of there dorsum. All rats in the diabetes groups (II, III, IV) are wounded 8 weeks after induction of diabetes. Wound surface area was measured at days 1, 3, 7,11,15, and 20 postoperative period.Time requriered for full healing also was measured. Results: The results showed that surface area of the wound in group I was lesser than group II (P