Journal of Semnan University of Medical Sciences
Smartphone-based application for training outpatient cardiac rehabilitation: Design and usability evaluation
Authors
Abstract
Introduction: Alzheimer’s disease (AD) is the most common cause of dementia worldwide. Mild cognitive impairment (MCI) is often the prodromal stage to AD. Most patients with MCI harbor the pathologic changes of AD and demonstrate transition to AD at a rate of 10–15% per year. Accumulating evidence indicates that the asymmetry changes of left and right brain have happened in the early stage of AD. However, the features of asymmetry changes in anterior cingulate cortex (ACC) is still unclear. Materials and Methods: We examined the left-right asymmetry changes of metabolites in ACC. In this account, 14 cases of mild AD patients meeting criteria for probable AD of NINDS-ADRDA, 12 cases of MCI according to the Mayo Clinic Alzheimer’s Disease Research Center criteria, and 15 cases of age-matched normal controls (NC) received Proton magnetic resonance spectroscopy (1H-MRS) for measurement of NAA/mI, NAA/Cr, Cho/Cr, and mI/Cr ratios in the ACC bilaterally. We analyzed MRS data by paired t-test to validate the left-right asymmetry of MRS data in the ACC. Results: In AD, there was a significant difference in mI/Cr between the left and right ACC (P
Copyright
© 2020, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
Similar Articles
Application of magnetic resonance spectroscopy for evaluating metabolic alteration in anterior cingulate cortex in Alzheimer’s disease
Saatchian E, Ehsani S, Montazerabadi A. Application of magnetic resonance spectroscopy for evaluating metabolic alteration in anterior cingulate cortex in Alzheimer’s disease. koomesh. 2020;22(4):e153228. doi:
Evaluation of Usage fMRI in Alzheimer’s Disease Diagnose
Yazdani S, Khoshgard K, Norouzi H. Evaluation of Usage fMRI in Alzheimer’s Disease Diagnose. I J Radiol. 2017;14(Special Issue):e93691. doi: https://doi.org/10.5812/iranjradiol.48279
Survey of potential diagnostic metabolite markers in serum of the rat model of Alzheimer’s disease using nuclear magnatic resonance (1H-NMR) technique
[email protected] F, Farrokhi-Yekta R, ArefiOskouie A, Eslami M. Survey of potential diagnostic metabolite markers in serum of the rat model of Alzheimer’s disease using nuclear magnatic resonance (1H-NMR) technique. koomesh. 2021;23(1):e153245. doi:
Comparison of Cognitive Functions Between Patients with Alzheimer Disease, Patients with Mild Cognitive Impairment, and Healthy People
Hedayatjoo M, Tehrani Doost M, Vahabi Z, Akbarfahimi M, Khosrowabadi R. Comparison of Cognitive Functions Between Patients with Alzheimer Disease, Patients with Mild Cognitive Impairment, and Healthy People. Arch Neurosci. 2023;10(1):e131408. doi: https://doi.org/10.5812/ans-131408
The Effect of Anterior Cingulate Cortex Direct Current Stimulation on Speech Monitoring Ability in Individuals with Aphasia: A Randomized, Double-Blinded Study
Tahanzadeh B, Khatoonabadi AR, Oveisgharan S, Jalaie S, Ashayeri H, et al. The Effect of Anterior Cingulate Cortex Direct Current Stimulation on Speech Monitoring Ability in Individuals with Aphasia: A Randomized, Double-Blinded Study. Arch Neurosci. 2018;5(3):e62055. doi: https://doi.org/10.5812/archneurosci.62055
More by these authors
- Scopus by DOI: 0
Last Update: 1 month ago
- Scopus by Title: 5
Last Update: 1 month ago
- Scopus by Title (Ref): 0
Last Update: 1 month ago
- CrossRef: 0
Last Update: 3 days ago