Preventive effects of progesterone on the electrophysiological response of sciatic nerve in the chronic constriction injury model of neuropathic pain in the rat

Morteza Jarrahi; Hossein Ali Safakhah; Roya Hasani; ali rashidypour

doi:10.5812/koomesh-154150

Koomesh

Journal of Semnan University of Medical Sciences

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Preventive effects of progesterone on the electrophysiological response of sciatic nerve in the chronic constriction injury model of neuropathic pain in the rat

Author(s):

Morteza Jarrahi^{1, 2,*},

Hossein Ali Safakhah^{3, 4},

Roya Hasani¹,

ali rashidypour^{3, 4}

1Laboratory of Neuropathic Pain and Electrophysiology, Research Center of Physiology, Semnan University of Medical Sciences, Semnan, Iran

2Dept. of Physiology, school of Medicine, Semnan University of Medical Sciences, Semnan, Iran

3- Laboratory of Neuropathic Pain and Electrophysiology, Research Center of Physiology, Semnan University of Medical Sciences, Semnan, Iran

4– Dept. of Physiology, school of Medicine, Semnan University of Medical Sciences, Semnan, Iran

Koomesh:Vol. 25, issue 2; e154150

Published online:Aug 26, 2023

Article type:Research Article

How to Cite:Jarrahi M, Safakhah HA, Hasani R, rashidypour A. Preventive effects of progesterone on the electrophysiological response of sciatic nerve in the chronic constriction injury model of neuropathic pain in the rat. koomesh. 2023;25(2):e154150. doi:

Abstract

Introduction: Peripheral neuropathy (PN) is resulted from damage to the peripheral nervous system (PNS) and usually causes weakness, numbness, and neuropathic pain, which is a type of chronic pain. Despite the variety of treatment options, treating neuropathic pain faces challenges and the existing treatments are not yet satisfactory. Nervous steroids show important physiological regulators of PNS function. Progesterone is a neurosteroid that has both analgesic and anti-inflammatory properties. Also, GABA-A receptors play an important role in mediating the effect of progesterone. This study was designed to determine whether progesterone can prevent electrophysiological deterioration of the sciatic nerve in the chronic constriction injury (CCI) model of neuropathic pain in rats and that do this effect through GABA-A receptors.
Materials and Methods: In this study, 140 male Wistar rats in 14 groups (n=10) were used. Neuropathic pain was created by the CCI method in the relevant groups. After CCI induction, progesterone and bicuculline or their vehicles were administered daily until day 13 post-CCI. After that, nerve conduction velocity (NCV) tests were performed according to Julu methods on days 14 and 27 after CCI.
Results: According to the findings of this study, daily injections of progesterone for 12 days before complete neuropathic pain evolution in CCI rats could prevent significantly the reduction of sensory and motor nerve conduction velocities compared to the CCI group on days 14 and 27 after CCI. Furthermore, this effect of progesterone was blocked by bicuculline administration
Conclusion: The findings of this study showed that before complete neuropathic pain evolution, chronic progesterone administration may prevent electrophysiological disorders of the sciatic nerve (at least to some extent through GABA-A receptors) in CCI-induced peripheral neuropathy and these effects continue in the accepted range time of the CCI mode.

Keywords

Preventive effects of progesterone against neuropathic pain responses in a rat model of chronic constriction injury

Morteza Jarrahi,

Roya Hasani,

A. li Rashidy-Pour,

Hossein ali Safakhah

Jarrahi M, Hasani R, Rashidy-Pour AL, Safakhah HA. Preventive effects of progesterone against neuropathic pain responses in a rat model of chronic constriction injury. koomesh. 2019;21(1):e153053. doi:

24

Dec

2021

Combined effect of chronic progesterone administration with compulsive exercise on prevention of TNF-α production and abnormal electrophysiological responses of sciatic nerve in Chronic Constriction injury pain model in rat

Hossein ali Safakhah,

Morteza Jarrahi,

ali rashidypour,

AhmadRez Babndegi,

Fariba Khazani

Safakhah HA, Jarrahi M, rashidypour A, Babndegi A, Khazani F. Combined effect of chronic progesterone administration with compulsive exercise on prevention of TNF-α production and abnormal electrophysiological responses of sciatic nerve in Chronic Constriction injury pain model in rat. koomesh. 2021;23(1):e154062. doi:

4

Jul

2021

Effects of combined chronic progesterone administration and forced exercise on behavioral pain responses in the neuropathic pain model of chronic constriction injury in rats

Fariba Khazani,

Morteza Jarrahi,

Ali Rashidy Pour,

Arefe Vafaeenejad,

Hossein ali Safakhah

Khazani F, Jarrahi M, Rashidy Pour A, Vafaeenejad A, Safakhah HA. Effects of combined chronic progesterone administration and forced exercise on behavioral pain responses in the neuropathic pain model of chronic constriction injury in rats. koomesh. 2021;23(2):e153266. doi:

15

Nov

2004

Role of saphenous nerve in the behavioral responses of neuropathic pain – due to chronic constriction injury in rats

Hossein ali Safakhah,

Homa Monahji

Safakhah HA, Monahji H. Role of saphenous nerve in the behavioral responses of neuropathic pain – due to chronic constriction injury in rats. koomesh. 2004;6(1):e152033. doi:

26

Aug

2023

The effects of co-administration of curcumin and forced exercise on electrophysiological responses in the neuropathic pain model of chronic constriction injury of peripheral nerves in rats

Hedyeh Baratzadeh,

Hossein Ali Safakhah,

Ali Rashidy Pour,

Morteza Jarrahi

Baratzadeh H, Safakhah HA, Rashidy Pour A, Jarrahi M. The effects of co-administration of curcumin and forced exercise on electrophysiological responses in the neuropathic pain model of chronic constriction injury of peripheral nerves in rats. koomesh. 2023;25(2):e154152. doi:

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Author(s):

Morteza Jarrahi:[PubMed][Scholar]
Hossein Ali Safakhah:[PubMed][Scholar]
Roya Hasani:[PubMed][Scholar]
ali rashidypour:[PubMed][Scholar]

Journal of Semnan University of Medical Sciences

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Preventive effects of progesterone on the electrophysiological response of sciatic nerve in the chronic constriction injury model of neuropathic pain in the rat

Abstract

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