Mannose Binding Lectin Serum Level and Gene Polymorphism in Patients with SLE and Its Relation to the Development of Lupus Nephritis

Kamal Okasha; Abeer Shahba; Nashwa Noor-eldeen; Azza Hassan; Hanan El-saadany; Amal El-Bendary

Nephro-Urology Monthly

Current Issue All Issues In Press Search Accepted Manuscripts

Journal Information Boards and Committees Indexing and Listing Sources Publication Ethics and Malpractice Statement Support Reviewer and AE Registration Form Contact Us Journal Metrics Open Peer Review (OPR)

APC

Authors Guide Submit Manuscript

Mannose Binding Lectin Serum Level and Gene Polymorphism in Patients with SLE and Its Relation to the Development of Lupus Nephritis

Author(s):

Kamal Okasha^1,*,

Abeer Shahba²,

Nashwa M. Noor-eldeen²,

Azza M. Hassan²,

Hanan El-saadany²,

Amal El-Bendary²

1Department of Internal Medicine/Nephrology Division,Faculty of medicine, Tanta University, [email protected], Egypt

2Department of Internal Medicine/Nephrology Division,Faculty of medicine, Tanta University, Egypt

Nephro-Urology Monthly:Vol. 2, issue 3; 401-413

Published online:Jul 31, 2010

Article type:Research Article

Received:Oct 02, 2009

Accepted:Nov 04, 2009

How to Cite:Okasha K, Shahba A, Noor-eldeen N, Hassan A, El-saadany H, et al. Mannose Binding Lectin Serum Level and Gene Polymorphism in Patients with SLE and Its Relation to the Development of Lupus Nephritis. Nephro-Urol Mon. 2010;2(3):. doi:

Abstract

Background and Aims: Systemic lupus erythematosus (SLE) is an autoimmune disease in which the complement system plays a crucial role in its pathogenesis. Mannan-binding lectin (MBL) is a recognition molecule of the lectin pathway of complement activation. The presence of several polymorphisms at the promoter and coding regions of the MBL-2 gene determines alterations at MBL serum concentration. MBL variant alleles that lead to low serum levels and/or functional deficits of MBL are postulated to contribute to the susceptibility of SLE. Moreover, the influence of MBL variation on antibody production and renal involvement in SLE patients remains controversial. Objectives: MBL serum level and genotypes were studied in our SLE Egyptian patients with evaluation of its role in auto antibodies production and lupus nephritis development.

Methods: MBL genotypes and serum level were screened in a case control study included 30 SLE patients as well as 30 healthy controls. MBL polymorphism at exon 1 codons 54 and 57 was detected by PCR using sequence-specific priming (SSP) and serum MBL level was determined by ELISA technique.

Results: There was predominance of AA genotype (80%) in control group. Genotype frequencies of MBL variants in patients with SLE showed significant differences when compared with controls (AA 53.3% vs 80%, P=0.03, OR = 0.29 and AO+OO 46.6% vs 20%, P = 0.03, OR = 3.5, respectively). Serum MBL in our SLE patients (900 ng/ml) was significantly lower than that of the control group (2750 ng/ml, P = 0.00) with positive correlation with low MBL genotypes. SLE patients with mutant alleles were more likely to produce anti dsDNA (92.8% vs 75%, OR = 4.3) and anti-Smith (35.7% vs 18.7%, OR = 2.3). Patients carrying MBL-low genotypes have an increased risk of development of lupus nephritis than those carrying MBL-high genotype (64.7% vs 35.2%, P = 0.02, OR= 2.4).

Conclusion: MBL gene polymorphism associated with low MBL serum levels that were found with significantly increased frequency in our SLE patients may be one of the genetic factors that determine the susceptibility to develop lupus nephritis.

Keywords

Mannose-Binding Lectin (MBL)

Systemic Lupus Erythematosus (SLE)

Lupus Nephritis (LN)

Gene Polymorphism

Full Text

Full text is available in PDF

Association of DD Genotype of Insertion/Deletion Polymorphism of Angiotensin-Converting Enzyme Gene with Systemic Lupus Erythematosus and Lupus Nephropathy

Saeedeh Salimi,

Anoosh Naghavi,

Zahra Zakeri,

Sima Nabizadeh,

Farzaneh Farajian-mashhadi,

Mahnaz Sandoughi

Salimi S, Naghavi A, Zakeri Z, Nabizadeh S, Farajian-mashhadi F, et al. Association of DD Genotype of Insertion/Deletion Polymorphism of Angiotensin-Converting Enzyme Gene with Systemic Lupus Erythematosus and Lupus Nephropathy. Zahedan J Res Med Sci. 2013;15(10):e92822. doi:

8

Feb

2017

Low Serum Mannose Binding Lectin (MBL) Levels and -221 YX Genotype of MBL2 Gene Are Susceptible to Neonatal Sepsis in the Chinese Han Population

Heng Xue,

Xiaoguang Xue,

Changyi Yang,

Qingquan Chen,

Ni Lin,

Yujun Lin

,et al.

Xue H, Xue X, Yang C, Chen Q, Lin N, et al. Low Serum Mannose Binding Lectin (MBL) Levels and -221 YX Genotype of MBL2 Gene Are Susceptible to Neonatal Sepsis in the Chinese Han Population. Inn J Pediatr. 2017;27(3):e9448. doi: https://doi.org/10.5812/ijp.9448

31

Mar

2007

Mannose Binding Lectin Gene Haplotype in Iranian Patients with Hepatitis C Infection

Mohammad Hossein Somi,

Sara Farhang,

Mohammad Asgharzadeh,

Rasoul Estakhry,

Ali Pouri

Somi M, Farhang S, Asgharzadeh M, Estakhry R, Pouri A. Mannose Binding Lectin Gene Haplotype in Iranian Patients with Hepatitis C Infection. Hepat Mon. 2007;7(1):. doi:

1

Nov

2013

Investigation of Mannose–Binding Lectin Level and Deficiency in Patients With Dermatophytosis

Mehraban Falahati,

Sanam Nami,

Farideh Zeini,

Mohsen Ghelman,

Zeinab Ghasemi,

Shima Nozari

Falahati M, Nami S, Zeini F, Ghelman M, Ghasemi Z, et al. Investigation of Mannose–Binding Lectin Level and Deficiency in Patients With Dermatophytosis. Jundishapur J Microbiol. 2013;6(9):e94140. doi: https://doi.org/10.5812/jjm.8255

30

Sep

2007

Comparison of serum lipoprotein (a) values in patients with systemic lupus erythematosus and healthy persons

S Almasi,

Z Rezaei,

MR Hatef,

M Sandoghi

Almasi S, Rezaei Z, Hatef M, Sandoghi M. Comparison of serum lipoprotein (a) values in patients with systemic lupus erythematosus and healthy persons. J Inflamm Dis. 2024;11(2):e155303. doi:

Import into EndNote Import into BibTex

Share on

Comments

Number of Comments:0

Cited by

Scopus by DOI: 0
Last Update: 1 week ago
Scopus by Title: 0
Last Update: 1 week ago
Scopus by Title (Ref): 3
Last Update: 1 week ago
CrossRef: 0
Last Update: 4 days ago

Metrics

Ordering Reprints

Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC

Search Relations

Author(s):

Kamal Okasha:[PubMed][Scholar]
Abeer Shahba:[PubMed][Scholar]
Nashwa Noor-eldeen:[PubMed][Scholar]
Azza Hassan:[PubMed][Scholar]
Hanan El-saadany:[PubMed][Scholar]
Amal El-Bendary:[PubMed][Scholar]

Outlines

Mannose Binding Lectin Serum Level and Gene Polymorphism in Patients with SLE and Its Relation to the Development of Lupus Nephritis

Abstract

Full Text

Similar Articles

Association of DD Genotype of Insertion/Deletion Polymorphism of Angiotensin-Converting Enzyme Gene with Systemic Lupus Erythematosus and Lupus Nephropathy

Low Serum Mannose Binding Lectin (MBL) Levels and -221 YX Genotype of MBL2 Gene Are Susceptible to Neonatal Sepsis in the Chinese Han Population

Mannose Binding Lectin Gene Haplotype in Iranian Patients with Hepatitis C Infection

Investigation of Mannose–Binding Lectin Level and Deficiency in Patients With Dermatophytosis

Comparison of serum lipoprotein (a) values in patients with systemic lupus erythematosus and healthy persons

Last Update: 1 week ago

Last Update: 1 week ago

Last Update: 1 week ago

Last Update: 4 days ago