Antioxidative Status in the Early Post-Transplant Period: Cyclosporine A-based vs Sirolimus-based Regimens

Mohsen Nafar; Mehri Kadkhodaee; Mitra Mazdeh; Maryam Zahmatkesh; Behjat Seifi; Rana Ghaznavi

Nephro-Urology Monthly

Home

Instructions

APC

Authors Guide Submit Manuscript

Outlines

Abstract
Copyright

Antioxidative Status in the Early Post-Transplant Period: Cyclosporine A-based vs Sirolimus-based Regimens

Author(s):

Mohsen Nafar¹,

Mehri Kadkhodaee¹,

Mitra Mahdavi Mazdeh^,,

Maryam Zahmatkesh¹,

Behjat Seifi¹,

Rana Ghaznavi¹

1Department of Nephrology, Shahid Beheshti University of Medical Sciences, IR.Iran

Nephro-Urology Monthly:Vol. 2, issue 2; 330-334

Published online:Apr 30, 2010

Article type:Research Article

Received:Sep 15, 2009

Accepted:Oct 09, 2009

How to Cite:Nafar M, Kadkhodaee M, Mazdeh M, Zahmatkesh M, Seifi B, et al. Antioxidative Status in the Early Post-Transplant Period: Cyclosporine A-based vs Sirolimus-based Regimens. Nephro-Urol Mon. 2010;2(2):. doi:

Abstract

Background and Aims: It is renowned that the principal causes of oxidative stress will disappear after transplantation. However, it does not seem to improve totally, which may be due to an immunologic response to the graft or possibly immunosuppressive agents. This study was conducted to investigate the possible relation between oxidative stress and different immunosuppressive regimens (cyclosporine versus sirolimus based) in renal transplant patients.

Methods: Twenty-five renal transplanted patients with uneventful operation and stable function were randomly assigned to one regimen of immunosuppressive protocols cyclosporine (CsA) (Group A) or sirolimus (Group B) plus mycophenolate mofetil (MMF) and Steroids. Erythrocyte Glutathione (GSH), Superoxide dismutase activity, plasma malondialdehyde (MDA) and α-tocopherol were measured and compared.

Results: There were no significant changes of SOD activity in CsA group in different days. However, there was a significant reduction of SOD activity in sirolimus group 14 days after transplantation. Erythrocyte GSH did not show any significant changes between the groups. Plasma MDA and vitamin E level were not significantly different between the groups before and 48 hour after transplantation.‍‍ Considerably higher MDA (1.82 ± 0.43 vs. 1.03 ± 0.12, µmol/l, p<0.05) and vitamin E levels (0.18 ± 0.008 vs. 0.12 ± 0.006 µmol/l, p<0.05) were seen 2 weeks after transplantation in sirolimus group compared to CsA group.

Discussion: The results of the present study showed that although sirolimus-treated recipients had decreased activity of SOD in 14^th day of transplantation but no alteration of GSH during this period in comparison with cyclosporine-treated recipients was found. Increased level of plasma vitamin E on 14^th day was possibly a secondary response to the change of MDA level.

Conclusions: It seems that sirolimus may not offer better protection against increased reactive oxygen species (ROS) production in early period of renal transplantation.

Keywords

Cyclosporine A

Sirolimus

Immunosuppressive Agent

Oxidative Stress

Full Text

Full text is available in PDF

Study of The Effects of N-Acetylcysteine on Oxidative Stress Status of Patients on Maintenance-Hemodialysis Undergoing Cadaveric Kidney Transplantation

Atieh Modarresi,

Shadi Ziaie,

Jamshid Salamzadeh,

Zahra Sahraei,

Mohsen Nafar,

Yunes Panahi

,et al.

Modarresi A, Ziaie S, Salamzadeh J, Sahraei Z, Nafar M, et al. Study of The Effects of N-Acetylcysteine on Oxidative Stress Status of Patients on Maintenance-Hemodialysis Undergoing Cadaveric Kidney Transplantation. Iran J Pharm Res. 2017;16(4):e125037. doi: https://doi.org/10.22037/ijpr.2017.2139

8

Jun

2020

A Triple-Blind Randomized Controlled Trial on Impacts of Pioglitazone on Oxidative Stress Markers in Diabetic Kidney Transplant Recipients

Ali Kharazmkia,

Shadi Ziaie,

Pedram Ahmadpoor,

Omid Moradi,

Ali Khoshdel,

Fatemeh Pour-Reza-Gholi

,et al.

Kharazmkia A, Ziaie S, Ahmadpoor P, Moradi O, Khoshdel A, et al. A Triple-Blind Randomized Controlled Trial on Impacts of Pioglitazone on Oxidative Stress Markers in Diabetic Kidney Transplant Recipients. Shiraz E-Med J. 2020;21(11):e98656. doi: https://doi.org/10.5812/semj.98656

1

Mar

2012

Change of Cyclosporine Absorption over the Time After Kidney Transplantation

Behzad Einollahi,

Mojtaba Teimoori,

Zohreh Rostami

Einollahi B, Teimoori M, Rostami Z. Change of Cyclosporine Absorption over the Time After Kidney Transplantation. Nephro-Urol Mon. 2012;4(2):470-474. doi: https://doi.org/10.5812/numonthly.2437

29

Jul

2015

Influence of Hemodialysis on Lipid Peroxidation, Enzymatic and Non-Enzymatic Antioxidant Capacity in Chronic Renal Failure Patients

Mehryar Zargari,

Omid Sedighi

Zargari M, Sedighi O. Influence of Hemodialysis on Lipid Peroxidation, Enzymatic and Non-Enzymatic Antioxidant Capacity in Chronic Renal Failure Patients. Nephro-Urol Mon. 2015;7(4):e28526. doi: https://doi.org/10.5812/numonthly.28526

25

Mar

2020

Prevention of Ischemia-Reperfusion Injury in Human Kidney Transplantation: A Meta-Analysis of Randomized Controlled Trials

Fariba Tohidinezhad,

Saeid Eslami,

Saba Vakili,

Mohsen Aliakbarian,

Mahmoud Tavakkoli

Tohidinezhad F, Eslami S, Vakili S, Aliakbarian M, Tavakkoli M. Prevention of Ischemia-Reperfusion Injury in Human Kidney Transplantation: A Meta-Analysis of Randomized Controlled Trials. Nephro-Urol Mon. 2020;12(2):e101590. doi: https://doi.org/10.5812/numonthly.101590

Import into EndNote Import into BibTex

Share on

Comments

Number of Comments:0

Cited by

Scopus by DOI: 0
Last Update: 2 weeks ago
Scopus by Title: 0
Last Update: 2 weeks ago
Scopus by Title (Ref): 0
Last Update: 2 weeks ago
CrossRef: 0
Last Update: 2 days ago

Metrics

Ordering Reprints

Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC

Search Relations

Author(s):

Mohsen Nafar:[PubMed][Scholar]
Mehri Kadkhodaee:[PubMed][Scholar]
Mitra Mazdeh:[PubMed][Scholar]
Maryam Zahmatkesh:[PubMed][Scholar]
Behjat Seifi:[PubMed][Scholar]
Rana Ghaznavi:[PubMed][Scholar]

Outlines

Antioxidative Status in the Early Post-Transplant Period: Cyclosporine A-based vs Sirolimus-based Regimens

Abstract

Full Text

Similar Articles

Study of The Effects of N-Acetylcysteine on Oxidative Stress Status of Patients on Maintenance-Hemodialysis Undergoing Cadaveric Kidney Transplantation

A Triple-Blind Randomized Controlled Trial on Impacts of Pioglitazone on Oxidative Stress Markers in Diabetic Kidney Transplant Recipients

Change of Cyclosporine Absorption over the Time After Kidney Transplantation

Influence of Hemodialysis on Lipid Peroxidation, Enzymatic and Non-Enzymatic Antioxidant Capacity in Chronic Renal Failure Patients

Prevention of Ischemia-Reperfusion Injury in Human Kidney Transplantation: A Meta-Analysis of Randomized Controlled Trials

Last Update: 2 weeks ago

Last Update: 2 weeks ago

Last Update: 2 weeks ago

Last Update: 2 days ago