Individual health is regarded as a complex interplay among biological, environmental, social, and political factors, which in turn should be considered in many instances because of their potential roles in health disparities (
1). This multi - faceted situation must be dealt with different aspects using a transdisciplinary framework addressing preventable factors that contribute to health disparities. Strong collaborations among governmental organizations, service providers, and other stakeholders including researchers and non-governmental organizations may provide opportunities to reach less disparity on population health, particularly in incidence and prevalence of diseases, morbidity and mortality, and access to health care, or survival rates (
2). In line with the I.R Iran's constitutional law (
3), vision for 2020 (
4,
5), and five - year socio - economic and cultural development plans of the Islamic Republic of Iran (
6), which all emphasize on reducing deprivation in different aspects, MOHME established the secretariat for social determinants of health. However, it has recently been upgraded to social deputy, which was designated as the focal point for coordinating actions on health disparities elimination (“Action for SDH”). In the past 10 years, based on a national SDH conceptual framework, major steps have been taken to identify major social factors that have led to health disparities. This paper reviews intersectoral actions which have been already formulized and implemented to reduce health disparities by the MOHME.