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Shiraz E-Medical Journal

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Abnormal Immunoglobulin Levels in Iranian Patients with Hematologic Malignancies.

Author(s):
MA Mashhadi MA Mashhadi1, HA Khazaei HA Khazaei2, B Narouie B Narouie3,*, AA Niazi AA Niazi 4, K Moazzami K Moazzami5, R Khademi R Khademi 6, F Hejazinia F Hejazinia 6, N Rezaei N Rezaei 5, M Ghasemi-rad M Ghasemi-rad7
1Assistant Professor, Section of Hematology, Department of Internal Medicine, Zahedan University of Medical Sciences, Zahedan, Iran,
2Associate Professor, Department of Immunology, Zahedan University of Medical Sciences, Zahedan, Iran,
3Researcher, Clinical Research Development Center, Zahedan University of Medical Sciences, Zahedan, Iran,
4Assistant Professor, Department of Pathology, Zahedan University of Medical Sciences, Zahedan, Iran,
5Immunology, Asthma and Allergy Research Institute, University of Tehran, Tehran, Iran,
6Registered Nurse, Zahedan University of Medical Sciences, Zahedan, Iran,
7Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran.
Shiraz E-Medical Journal:Vol. 10, issue 3; 120-5
Published online:Jul 01, 2009
Article type:Research Article
Received:May 10, 2009
Accepted:May 26, 2009
How to Cite:Mashhadi M, Khazaei H, Narouie B, Niazi A, Moazzami K, et al. Abnormal Immunoglobulin Levels in Iranian Patients with Hematologic Malignancies.. Shiraz E-Med J. 2009;10(3):. doi:

Abstract

Abstract:

Introduction: Hematologic malignancies can be associated with dysregulation of the immune system. There are some conflicting data regarding serum immunoglobulin levels in patients with such malignancies. Material and method: In order to evaluate the humoral immunity of the patients with hematologic malignancies, 58 patients were enrolled in this study. 24 with acute lymphoblastic leukemia (ALL), 17 with acute myeloid leukemia (AML), eight with lymphoma, five with chronic lymphocytic leukemia, and four with multiple myeloma. Results: There were six cases with decreased serum IgG level (5 AML and 1 ALL). Forty patients with elevated serum IgG levels (69%).24 with elevated IgA and/or IgM level; 12 patients with elevation in all classes of immunoglobulin (8 ALL, 2 AML, and 2 lymphoma). Conclusion: Serum immunoglobulin levels can be abnormal in the patients with hematologic malignancies. Abnormalities of IgG, especially elevated level, seem to be the most frequent finding encountered in these patients.

Keywords
Hematologic malignancies
Immunoglobulin
Leukemia
Lymphoma

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