Fulltext
Fulltext is availale in the PDF.
Zahedan Journal of Research in Medical Sciences
The Official Journal of Zahedan University of Medical Sciences
e-ISSN 2383-2894
Image Credit:Zahedan J Res Med Sci
Outline
Amelioration of Glomerulosclerosis by Satureja khozestanica Essential Oil in A lloxan-Induced Diabetic Rats
Authors
1Department of Anatomy, Lorestan Univers ity of Medical Sciences , Khoramabad, Iran
2Department of Biochemistry, Razi Herbal Researches Center , Lorestan University of Medical Sciences,, Khoramabad, Iran
*Corresponding Author: Department of Biochemistry, Razi Herbal Researches Center , Lorestan University of Medical Sciences,, Khoramabad, Iran Email: hassan_a46@yahoo.com
Zahedan Journal of Research in Medical Sciences:Vol. 16, issue 10
Published online:Nov 25, 2013
Article type:Research Article
Received:Mar 10, 2013
Accepted:May 28, 2013
How to Cite:Tavafi M, Ahmadvand H. Amelioration of Glomerulosclerosis by Satureja khozestanica Essential Oil in A lloxan-Induced Diabetic Rats. Zahedan J Res Med Sci. 2014;16(10):. doi:
Abstract
Background: Satureja khuzestanica, an endemic plant of Iran, has been reported to be used traditionally to treat diabetes. We examined possible protective effect of Satureja khozestanica essential oil (SKE) on glomerulosclerosis in alloxan-induced type 1 diabetic rats.
Materials and Methods: In this experimental study, 30 Sprage-dawley male rats were divided into 3 groups randomly; group 1 as control, group 2 diabetic untreated, and group 3 treatments with SKE by 500 ppm in drinking water, respectively. Diabetes was induced in the second and third groups by alloxan injection subcutaneously. After 8 weeks, animals were anaesthetized; livers and kidneys were then removed immediately. Kidney paraffin sections were prepared and stained by periodic acid Schiff method. Glomerular volume and leukocyte infiltration were estimated by stereological rules and glomerular sclerosis was studied semi-quantitatively.
Results: Flow treatment of diabetic animals with SKE could significantly inhibit glomerular hypertrophy (22%) leukocyte infiltration (31%) and glomerulosclerosis (20%) in comparison with the diabetic untreated group.
Conclusion: The findings showed that SKE alleviates loss of glomerular volume, leukocyte infiltration, and glomerulosclerosis and exerts beneficial effects on the lipid peroxidation in alloxan-induced type 1 diabetic rats.
Highlights
References
- 1.References are available in the PDF.
Copyright
© 2014, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
Similar Articles
30
Dec
2012
Hypolipidemic and Antiatherogenic Effects of Satureja Khozestanica Essential Oil in Alloxan-Induced Type 1 Diabetic Rats
Hassan Ahmadvand,
Majid Tavafi,
Gholamreza Shahsavari,
Ali Khosrobeigi,
Shahrokh Bagheri,
Foad Abdolahpour
Ahmadvand H, Tavafi M, Shahsavari G, Khosrobeigi A, Bagheri S, et al. Hypolipidemic and Antiatherogenic Effects of Satureja Khozestanica Essential Oil in Alloxan-Induced Type 1 Diabetic Rats. Zahedan J Res Med Sci. 2013;15(8):e92900. doi:
31
Oct
2012
Hepatoprotective and Hypolipidemic Effects of Satureja Khuzestanica Essential Oil in Alloxan-induced Type 1 Diabetic Rats
Hassan Ahmadvand,
Majid Tavafi,
Ali Reza Khalatbary
Ahmadvand H, Tavafi M, Khalatbary AR. Hepatoprotective and Hypolipidemic Effects of Satureja Khuzestanica Essential Oil in Alloxan-induced Type 1 Diabetic Rats. Iran J Pharm Res. 2012;11(4):e125892. doi: https://doi.org/10.22037/ijpr.2012.1213
31
Oct
2012
Hepatoprotetive, Cardioprotective and Nephroprotective Actions of Essential Oil Extract of Artemisia sieberi in Alloxan Induced Diabetic Rats
Fawzi Irshaid,
Kamal Mansi,
Ahmad Bani-Khaled,
Talal Aburjia
Irshaid F, Mansi K, Bani-Khaled A, Aburjia T. Hepatoprotetive, Cardioprotective and Nephroprotective Actions of Essential Oil Extract of Artemisia sieberi in Alloxan Induced Diabetic Rats. Iran J Pharm Res. 2012;11(4):e125878. doi: https://doi.org/10.22037/ijpr.2012.1214
8
Sep
2021
Salvia Officinalis Protects Pancreatic Beta-cells Against Streptozotocin-Induced Damage; A Stereological Study
Soheil Ashkani-Esfahani,
Ali Noorafshan,
Alireza Ebrahimi,
Maryam Bahmani-Jahromi,
Mohammad-Hossein Imanieh,
Sedigheh Ebrahimi
,et al.Ashkani-Esfahani S, Noorafshan A, Ebrahimi A, Bahmani-Jahromi M, Imanieh M, et al. Salvia Officinalis Protects Pancreatic Beta-cells Against Streptozotocin-Induced Damage; A Stereological Study. Jundishapur J Nat Pharm Prod. 2022;17(1):e109906. doi: https://doi.org/10.5812/jjnpp.109906
26
May
2013
The Inhibitory Effect of Satureja khozestanica Essential Oil and Carvacrol on Nitric Oxide Production in Macrophage Cell Line
Masumeh Jalalvan,
Gholamreza Shahsavari,
Ghasem Mosayebi
Jalalvan M, Shahsavari G, Mosayebi G. The Inhibitory Effect of Satureja khozestanica Essential Oil and Carvacrol on Nitric Oxide Production in Macrophage Cell Line. Zahedan J Res Med Sci. 2014;16(3):. doi:
Cited by
- Scopus by DOI: 0
Last Update: 1 week ago
- Scopus by Title: 0
Last Update: 1 week ago
- Scopus by Title (Ref): 0
Last Update: 1 week ago
- CrossRef: 0
Last Update: 7 hours ago
- OpenAlex: 0
Last Update: 10 hours ago
- OpenCitations: 0
Last Update: 5 days ago
Comments
Number of Comments:0