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Zahedan Journal of Research in Medical Sciences
The Official Journal of Zahedan University of Medical Sciences
Outlines
Comparison Between the Effects of the Alcholic Extract of Mellissia Officinalis and Atorvastatin on Serum Levels of Thyroid Hormones in Hypercholesterolemic Male Rats
Author(s):
Ali Zarei1, Saeed Changizi Ashtiyani2,*, Mansour Sokhandani3, Azam Rezaei4, Saeed Zaheiri5, Soheila Taheri61Department of Physiology, Science and Research Branch, Azad University of Damghan, Damghan, Iran
2Department of Physiology, Arak University of Medical Sciences, Arak, Iran
3Department of Nursing, Shiraz University of Medical Sciences, Shiraz, Iran
4Department of Physiology, Azad University of Arsanjan, Arsanjan, Iran
5Department of Biology, Payam-e-Noor University, Tehran, Iran
6Staff of Education Development Center, Arak University of Medical Sciences, Arak, Iran
*Corresponding Author: Department of Physiology, Arak University of Medical Sciences, Arak, Iran Email: [email protected]
Published online:Dec 30, 2012
Article type:Research Article
Received:May 09, 2012
Accepted:Oct 14, 2012
How to Cite:Zarei A, Changizi Ashtiyani S, Sokhandani M, Rezaei A, Zaheiri S, et al. Comparison Between the Effects of the Alcholic Extract of Mellissia Officinalis and Atorvastatin on Serum Levels of Thyroid Hormones in Hypercholesterolemic Male Rats. Zahedan J Res Med Sci. 2013;15(8):e92894. doi:
Abstract
Background: Consumption of unsaturated fats reduces the serum level of lipids and leptin.
Thyroid hormones and leptin play pivotal roles in metabolism and their amounts are interrelated.
This study was done to compare the effects of Mellissia officinalis extract and
atorvastatin on the serum levels of thyroid hormones in hypercholesterolemia rats.
Materials and Methods: Consumption of unsaturated fats reduces the serum level of lipids
and leptin. Thyroid hormones and leptin play pivotal roles in metabolism and their
amounts are inter-related. This study was done to compare the effects of Mellissia
officinalis extract and atorvastatin on the serum levels of thyroid hormones in
hypercholesterolemia rats.
Results: The results showed that in experimental groups receiving the plant extract and
atorvastatin, the concentration of thyroid hormones increased, whereas the amount of the
thyroid-stimulating hormone showed a significant decrease (p<0.05).
Conclusion: Mellissia officinalis extract decreases TSH but it increases T3 and T4. Further
studies are required for applying this extract to the treatment of hyperthyroidism.
References
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Copyright
© 2013, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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