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Zahedan Journal of Research in Medical Sciences
The Official Journal of Zahedan University of Medical Sciences
e-ISSN 2383-2894
Image Credit:Zahedan J Res Med Sci
Outline
Effects of Chronic 5-Bromo-2-Deoxyuridine Administration on Spatial Memory in the Adult Rats
Authors
1Department of Physiology, Mashhad University of Medical Sciences, Mashhad, Iran
2Department of Anatomy, Mashhad University of Medical Sciences, Mashhad, Iran
*Corresponding Author: Department of Anatomy, Mashhad University of Medical Sciences, Mashhad, Iran Email: mohammadia881@mums.ac.ir
Published online:Nov 18, 2012
Article type:Research Article
Received:Feb 21, 2012
Accepted:Oct 22, 2012
How to Cite:Hosseini M, Mohammadi pour A, Feizpour A, Ebrahimi V. Effects of Chronic 5-Bromo-2-Deoxyuridine Administration on Spatial Memory in the Adult Rats. Zahedan J Res Med Sci. 2013;15(5):e92977. doi:
Abstract
Background : 5-Bromo-2-deoxyuridine (BrdU) has been a principal marker for mitotic cells in studies of adult neurogenesis. The method consists of a pulse injection of BrdU into the intraperitoneal cavity followed by a variable survival time allowing for tracking the divided cells and their progeny. However, such exogenous markers may produce toxic effects. Aim of this study was determined the effects of Brdu on spatial memory in the adult rat.
Materials and Methods : 16 Wistar rats were used in this experimental study. The rats were randomly divided into 2 groups (N=8 in each group), as follows: control and Brdu (50 mg/kg). Brdu was administered intraperitoneally for 6 weeks and then animals were used for behavioral testing in the Morris water maze. The data were analyzed with repeated measure’s ANOVA.
Results : Our present findings show that there were no differences in the path length, escape latency and swim speed between control and Brdu-administrated groups.
Conclusion : This study show that Brdu (exogenic proliferation marker) did not has side effects on spatial memory in the adult rats.
Highlights
References
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Copyright
© 2013, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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