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Zahedan Journal of Research in Medical Sciences
The Official Journal of Zahedan University of Medical Sciences
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The Antimicrobial Activity of Grape Seed Extract against Two Important Oral Pathogens
Author(s):
Mahkameh Mirkarimi1,*, S.Mahmoud Amin-Marashi2, Majid Bargrizan3, Amir Abtahi4, Abbas Ali Imani Fooladi51Department of Pediatric Dentistry, Children and Adolescent Health Research Center, Faculty of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran
2Department of Microbiology and Immunology, Babol University of Medical Sciences, Babol, Iran
3Department of Pediatric Dentistry, Faculty of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4Dentist, Tehran, Iran
5Applied Microbiology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
*Corresponding Author: Department of Pediatric Dentistry, Children and Adolescent Health Research Center, Faculty of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran Email: [email protected]
Published online:Oct 14, 2012
Article type:Research Article
Received:Mar 05, 2012
Accepted:Jul 25, 2012
How to Cite:Mirkarimi M, Amin-Marashi S, Bargrizan M, Abtahi A, Imani Fooladi AA. The Antimicrobial Activity of Grape Seed Extract against Two Important Oral Pathogens. Zahedan J Res Med Sci. 2013;15(1):e93147. doi:
Abstract
Background : The antimicrobial properties of plant extracts have shown promise for development of new drugs. This study was conducted to measure the antibacterial activity of grape (Vitis vinifera) seed extract against Streptococcus mutans and Aggregatibacter actinomycetemcomitans.
Materials and Methods : In this experimental study the grape seed extract have been prepared with maceration method. The antimicrobial activity of the extract was examined by determining Minimum Inhibitory Concentration (MIC) and Minimal Bactericidal Concentration (MBC) using the macro dilution broth technique.
Results : MIC and MBC for Aggregatibacter actinomycetemcomitans was 3.84 mg/mL and 7.68 mg/mL respectively.There were not any inhibitory effects against Streptococcus mutans.
Conclusion : The Grape seed extract has inhibitory and bactericidal effects against Aggregatibacter actinomycetemcomitans. There were not any bactericidal or bacteriostatic effects against Streptococcus mutans.
References
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Copyright
© 2013, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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