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Zahedan Journal of Research in Medical Sciences
The Official Journal of Zahedan University of Medical Sciences
e-ISSN 2383-2894
Outline
The Relationship between Interleukin-6 -174 G/C Gene Polymorphism and Chronic Periodontitis
Authors
Tayebeh Sanchooli1, Hamidreza Mahmoudzadeh-Sagheb1,*, Hamidreza Mahmoudzadeh-Sagheb1, Mohammad Hashemi2, Mohammad Ayub Rigi-Ladiz3
1Department of Histology, Research Center for Infectious Diseases and Tropical Medicine, Boo-Ali Hospital, Zahedan University of Medical Sciences, Zahedan, Iran
2Department of Clinical Biochemistry, Cellular and Molecular Research Center, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
3Department of Periodontology, Faculty of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran
*Corresponding Author: Department of Histology, Research Center for Infectious Diseases and Tropical Medicine, Boo-Ali Hospital, Zahedan University of Medical Sciences, Zahedan, Iran Email: [email protected]
Published online:Mar 18, 2012
Article type:Research Article
Received:Dec 20, 2011
Accepted:Jan 12, 2012
How to Cite:Sanchooli T, Mahmoudzadeh-Sagheb H, Mahmoudzadeh-Sagheb H, Hashemi M, Rigi-Ladiz MA. The Relationship between Interleukin-6 -174 G/C Gene Polymorphism and Chronic Periodontitis. Zahedan J Res Med Sci. 2012;14(3):e93544. doi:
Abstract
Background: Chronic periodontitis is an inflammatory disease that causes rapid destruction of the tissues supporting the teeth. Genetic and environmental factors are involved in its occurrence. It has been suggested that IL-6 promoter gene polymorphism could affect the severity of chronic periodontitis. This study has examined the relationship between IL-6 (-174G/C) gene polymorphism and chronic periodontitis.
Materials and Methods: In this case-control study, 100 patients with chronic periodontitis and 100 healthy individuals referring to the clinic of Zahedan Dental School were evaluated. Two ml of peripheral blood was taken from these people. After DNA extraction through salting out method, IL-6 gene polymorphism was determined through T-ARMS-PCR technique using specific primers. The data were analyzed by chi-square test and p<0/05was considered significant.
Results: The frequency of genotypes CC, GC, GG was respectively 61%, 35% and 4% in patients and respectively 67%, 31% and 2% in the control group. The frequency of G and C alleles was respectively 78.5% and 21.5% in the patient group, and respectively 82.5% and 17.5% in control group. No statistically significant difference was observed between the two groups in frequency of genotypes and alleles.
Conclusion: This study showed no correlation between IL-6-174 G/C gene polymorphism and chronic periodontitis.
References
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Copyright
© 2012, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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