The antifungal effect of sodium hypo chloride in infected root canals with Candida albicans

Eshagh Ali  Saberi; Adel  Ebrahimzadeh; MH Ghanbari Phiroozabadi

Zahedan Journal of Research in Medical Sciences

The Official Journal of Zahedan University of Medical Sciences

Zahedan Journal of Research in Medical Sciences

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The antifungal effect of sodium hypo chloride in infected root canals with Candida albicans

Author(s):

Eshagh Ali Saberi^1,*,

Adel Ebrahimzadeh²,

MH Ghanbari Phiroozabadi³

1Endodontics dept, Faculty of dentistry, Zahedan University of Medical Sciences and health services, Zahedan, Iran.

2Parasitology and Mycology dept, Faculty of medicine, Zahedan University of Medical Sciences and health services, Zahedan, Iran.

3Dentist.

Zahedan Journal of Research in Medical Sciences:Vol. 6, issue 2; e95021

Published online:Jun 21, 2004

Article type:Research Article

Received:May 26, 2004

Accepted:Jun 09, 2004

How to Cite:Saberi EA, Ebrahimzadeh A, Ghanbari Phiroozabadi M. The antifungal effect of sodium hypo chloride in infected root canals with Candida albicans. Zahedan J Res Med Sci. 2004;6(2):e95021. doi:

Abstract

Background: Whereas sodium hypochlorite is the most commonly irrigation solution used in
endodontics we set out to study its antifungal effect of sodium hypochlorite in infected root
canals with candida albicans.
Methods and Materials: In this study 160 human maxillary incisor teeth extracted for
different reasons were selected. The teeth were cut in the CEJ zone and then the canals were
prepared by using hand files and Gattes Glidden bur no. 6. The roots were then divided across
into 5- mm pieces and using diamond disks and chisel so the sample volume will become 320
pieces halved each 5- mm piece. The root samples were divided randomly into two groups of
150. In one of the groups in order to remove the smear layer with EDTA 17% and then 5.25%
sodium hypochlorite. The smear layer in the other group remained intact. In addition 10
samples were selected as positive control and 10 samples as negative control. The samples
were then sterilized separately by autoclave.
320 sterilized tissue culture plates were selected. Each root sample was fixed in the bottom
of a plate, and contaminated with candida albicans and then exposed to 2.5% and 5.25%
sodium hypochlorite. 25 samples were taken from each group in intervals of 5، 30 and 60
minutes and transferred to the T.S.B culture medium. After 24 hours, the tubes containing
T.S.B were considered in presence of turbidity. The results were statistically analyzed.
Results: The results indicated that 2.5% sodium hypochlorite in the present of smear layer
caused destruction of candida albicans after 5 minutes in 20% of the cases while such
destruction happened with 5.25% sodium hypochlorite in 44% of the cases. However by
increasing the disinfections period in both concentrations the antifungal effect appears in
100% of the cases. Moreover the results of the study indicated in the group with no smear
layer, sodium hypochlorite with a concentration of 2.5% showed its antifungal effect in 5
minutes in 36% of the cases and with a concentration of 5.25% in 100% of the cases.
Conclusions: Therefore the use of specific antifungal irrigation solution in the endodontic
therapy of patients having local or systemic predisposing factors to oral candidiasis extreme
importance.

Keywords

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References

1.
The References of this article are available on the PDF file.

Evaluating the Effectiveness of Iranian and Korean Injectable Intracanal Calcium Hydroxide on Candida albicans, In vitro

Neda Rafiei,

Behrooz Eftekhar,

Abdollah Rafiei,

Mahdi Pourmahdi Borujeni,

Majid Zarrin

Rafiei N, Eftekhar B, Rafiei A, Pourmahdi Borujeni M, Zarrin M. Evaluating the Effectiveness of Iranian and Korean Injectable Intracanal Calcium Hydroxide on Candida albicans, In vitro. Jundishapur J Microbiol. 2012;5(3):e75788. doi: https://doi.org/10.5812/jjm.3409

27

Jun

2010

Antimicrobial evaluation of gutta-percha point containing calcium hydroxide and calcium hydroxide paste in infected root canal

Eshagh A Saberi,

Narges Farhad-Molashahi,

Mehdi Mohammadi

Saberi EA, Farhad-Molashahi N, Mohammadi M. Antimicrobial evaluation of gutta-percha point containing calcium hydroxide and calcium hydroxide paste in infected root canal. Zahedan J Res Med Sci. 2010;12(2):e94308. doi:

1

Jul

2013

Antifungal Efficacy of Aqueous and Gaseous Ozone in Root Canals Infected by Candida albicans

Ihsan Hubbezoglu,

Recai Zan,

Tutku Tunç,

Zeynep Sumer,

Feridun Hurmuzlu

Hubbezoglu I, Zan R, Tunç T, Sumer Z, Hurmuzlu F. Antifungal Efficacy of Aqueous and Gaseous Ozone in Root Canals Infected by Candida albicans. Jundishapur J Microbiol. 2013;6(5):e8150. doi: https://doi.org/10.5812/jjm.8150

14

Jun

2014

Evaluation of Hydroxyl Ion Diffusion in Dentin and Injectable Forms and a Simple Powder-Water Calcium Hydroxide Paste: An in Vitro Study

Behrooz Eftekhar,

Eskandar Moghimipour,

Ebrahim Eini,

Mansour Jafarzadeh,

Narges Behrooz

Eftekhar B, Moghimipour E, Eini E, Jafarzadeh M, Behrooz N. Evaluation of Hydroxyl Ion Diffusion in Dentin and Injectable Forms and a Simple Powder-Water Calcium Hydroxide Paste: An in Vitro Study. Jundishapur J Nat Pharm Prod. 2014;9(3):e14029. doi: https://doi.org/10.17795/jjnpp-14029

7

Sep

2011

Comparing the effects of Sodium Dichloroisocyanate (NaDCC) and Sodium Hypochlorite (NaOCL) on gram negative bacteria

meghdad pirsaheb,

Mohamad Soltanian,

Parasto Karimi,

Kiomars Sharafi

pirsaheb M, Soltanian M, Karimi P, Sharafi K. Comparing the effects of Sodium Dichloroisocyanate (NaDCC) and Sodium Hypochlorite (NaOCL) on gram negative bacteria. Zahedan J Res Med Sci. 2012;13(suppl 1):e95257. doi:

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Author(s):

Eshagh Ali Saberi:[PubMed][Scholar]
Adel Ebrahimzadeh:[PubMed][Scholar]
MH Ghanbari Phiroozabadi:[PubMed][Scholar]

The Official Journal of Zahedan University of Medical Sciences

Outlines

The antifungal effect of sodium hypo chloride in infected root canals with Candida albicans

Abstract

Fulltext

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