Relationship between Vitamin D and Childhood Asthma: A Case–Control Study

Shokrollah  Farrokhi; Gissou  Hatami; Khadijeh  Ghasemi; Niloofar  Motamed; Saiideh  Firoozbakht; Ali  Movahed

IJ Pediatrics

The Scientific Journal of Growth & Development Research Center

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Relationship between Vitamin D and Childhood Asthma: A Case–Control Study

Author(s):

Shokrollah Farrokhi^1,*,

Gissou Hatami²,

Khadijeh Ghasemi³,

Niloofar Motamed⁴,

Saiideh Firoozbakht⁵,

Ali Movahed⁶

IJ Pediatrics:Vol. 24, issue 6; 710-714

Published online:Nov 07, 2014

Article type:Research Article

Received:Nov 24, 2013

Accepted:Sep 03, 2014

How to Cite:Shokrollah FarrokhiGissou HatamiKhadijeh GhasemiNiloofar MotamedSaiideh FiroozbakhtAli Movahedet al.Relationship between Vitamin D and Childhood Asthma: A Case–Control Study.Iran J Pediatr.24(6):710-714.

Abstract

Objective: Studies determining the relationship between serum vitamin D status and childhood asthma have yielded controversial results. Findings indicated that vitamin D deficiency is associated with asthma and airway hyper responsiveness. The aim of this study was to assess the relationship between serum vitamin D status and childhood asthma. Methods: Data were obtained from 200 asthmatic children (age 3-12 years) and 200 healthy controls. Serum levels of 25(OH) vitamin D, total IgE, calcium, phosphorus, parathormone (PTH) and eosinophil count were measured in both asthmatic children and healthy controls. Also, the mean values of 25(OH) vitamin D were compared with asthma symptom severities. Findings: There was a significant decrease in the concentration of serum 25(OH) vitamin D in the asthmatic patients as compared with the controls (20.34±2.8 vs 25.39±4.1 ng/mL, 95%CI: 1.46-3.86, P=0.01). Out of total asthmatic subjects, 40 (20%) were vitamin D sufficient, 48 (24%) were insufficient, and 112 (56%) were deficient. Total IgE concentration was also significantly higher in asthmatic patients having vitamin D deficiency (132.4±20.1 IU/ml, 95%CI: 1.38-3.75, P=0.03). Comparing asthmatic patients with healthy controls, odds of having vitamin D level less than 20ng/mL was 2.47. Conclusion: Our findings suggest that vitamin D deficiency or insufficiency may be positively related to the prevalence of asthma in children.

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