Aquaretic Activity of Solidago canadensis L. Cultivated in Egypt and Determination of the Most Bioactive Fraction

Passent Mahmoud Abdel Baki; Moshera Mohamed El-Sherei; Amal Elsayed Khaleel; Amira Ahmed Abdel Motaal; Heba Mohammed Ibrahim Abdallah

doi:10.22037/ijpr.2019.2390

IJ Pharmaceutical Research

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https://doi.org/10.22037/ijpr.2019.2390

Aquaretic Activity of Solidago canadensis L. Cultivated in Egypt and Determination of the Most Bioactive Fraction

Author(s):

Passent Mahmoud Abdel Baki^1,*,

Moshera Mohamed El-Sherei¹,

Amal Elsayed Khaleel¹,

Amira Ahmed Abdel Motaal²,

Heba Mohammed Ibrahim Abdallah³

1Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Kasr El-Aini St., Cairo 11562, Egypt

2Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha, Kingdom of Saudi Arabia

3Department of Pharmacology, Medical Research Division, National Research Center, Giza 12622, Egypt

IJ Pharmaceutical Research:Vol. 18, issue 2; 922-937

Published online:May 01, 2019

Article type:Research Article

Received:Feb 22, 2017

Accepted:Apr 07, 2018

How to Cite:Passent Mahmoud Abdel BakiMoshera Mohamed El-ShereiAmal Elsayed KhaleelAmira Ahmed Abdel MotaalHeba Mohammed Ibrahim AbdallahAquaretic Activity of Solidago canadensis L. Cultivated in Egypt and Determination of the Most Bioactive Fraction.Iran J Pharm Res.18(2):e126230.https://doi.org/10.22037/ijpr.2019.2390.

Abstract

Despite the traditional use of Solidago canadensis L. (Asteraceae) as a diuretic drug, there is a scarcity in scientific data concerning the activity of its different extracts and fractions as well as the class of constituents responsible for this diuretic action. A comparative study was carried out for the diuretic activities of the different standardized extracts and fractions of the flowering aerial parts of S. canadensis, as well as isolation of compounds from the most biologically active fraction. The ethanol extract and its ethyl acetate fraction (EA) showed the highest aquaretic activities (91 and 58% at a dose of 400 mg/Kg b.wt., respectively) compared to 100% of furosemide at 20 mg/Kg b.wt.. Their activities were higher than Cystinol® and spironolactone reference standards (74% and 59% of furosemide, respectively). EA showed the highest total phenolic and flavonoid contents among the tested fractions of the ethanol and aqueous extracts (9.38 ± 0.004 g GAE and 39.75 ± 0.005 g RE/100 g dried extract, respectively). Eight flavonoids, 2 phenolic acids and 1 nucleoside were isolated from EA. This is the first report of a comparative study between the aquaretic activities of the different extracts, fractions and essential oil of S. canadensis, as well as isolation of thyimidine (1), isorhamnetin-3-O-β-ᴅ-glucopyranoside (2), kaempferol-3-O-(6”-O-acetyl)-β-ᴅ-glucopyranoside (4), quercetin-3-O-(6”-O-acetyl)-β-ᴅ-glucopyranoside (5), and kaempferol-3-O-β-ᴅ-apiofuranoside (7) from genus Solidago.

Keywords

Thymidine

Saponins

Phenolics

Kaempferol-3-O-β-ᴅ-apiofuranoside

Flavonoids

Aquaretic activity

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Author(s):

Passent Mahmoud Abdel Baki:[PubMed][Scholar]
Moshera Mohamed El-Sherei:[PubMed][Scholar]
Amal Elsayed Khaleel:[PubMed][Scholar]
Amira Ahmed Abdel Motaal:[PubMed][Scholar]
Heba Mohammed Ibrahim Abdallah:[PubMed][Scholar]