Antioxidant Activity of Otostegia persica (Labiatae) and its Constituents

authors:

avatar Fariba Shrififar 1 , avatar Nargess Yassa 1 , * , avatar Abbas Shafiee 2

Department of Pharmacognosy, School of Pharmacy, Tehran University of Medical Sciences and Health Services, Tehran, Iran
Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences and Health Services, Tehran, Iran
Iranian Journal of Pharmaceutical Research: Vol.2, issue 4; 235-239
published online: November 20, 2010
article type: Research Article
received: August 01, 2003
accepted: November 01, 2003
DOI: https://doi.org/10.22037/ijpr.2010.62

how to cite: Shrififar F, Yassa N, Shafiee A. Antioxidant Activity of Otostegia persica (Labiatae) and its Constituents. Iran J Pharm Res. 2003;2(4):e127964. https://doi.org/10.22037/ijpr.2010.62.

Abstract

The antioxidant activity of the different extracts and fractions of aerial parts of Otostegia persica (Burm.) Boiss. were evaluated using beta-carotene bleaching and lipid peroxidation methods. The inhibitory activity of the plant extracts on the peroxidation of linoleic acid were measured by ferric thiocyanate method in comparison to methanolic extracts of Green tee, Ginkgo biloba, Vit.E and BHA as positive controls. Methanolic extract of the plant exhibited strong antioxidant activity .Two compounds of methanolic extract which were separated by column and paper chromatography showed significant antioxidant activity comparable to butylated hydroxy anisole (BHA) and alpha tocopherol. These active compounds were identified as morin and quercetin by using UV, IR, MS, 1H and 13C NMR.