Study on the Effect of Paliurus spina-christi on Cholesterol, Triglyceride and HDL Levels in Diabetic Male Rats Fed a High Cholesterol Diet

authors:

avatar Mahmoud Mosaddegh 1 , * , avatar Mohammad Javad Khoshnood 2 , avatar Mohammad Kamalinejad 1 , avatar Elham Alizadeh 2

Traditional Medicine and Materia Medica Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
School of Pharmacy, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
Iranian Journal of Pharmaceutical Research: Vol.3, issue 1; 51-54
published online: November 20, 2010
article type: Research Article
received: October 01, 2003
accepted: February 01, 2004
DOI: https://doi.org/10.22037/ijpr.2010.297

how to cite: Mosaddegh M, Khoshnood M J, Kamalinejad M, Alizadeh E. Study on the Effect of Paliurus spina-christi on Cholesterol, Triglyceride and HDL Levels in Diabetic Male Rats Fed a High Cholesterol Diet. Iran J Pharm Res. 2004;3(1):e127983. https://doi.org/10.22037/ijpr.2010.297.

Abstract

Paliurus spina-christi Mill (Rhamnaceae) has been used in folk medicine as a hypocholesterolemic agent. In this study, the effect of total fruit extract on lowering lipid content of serum was investigated. Male rats were introduced streptozocin, subsequently fed with a high cholesterol diet and concomitantly treated with various doses of the extract. After 8 days, serum levels of cholesterol, triglyceride and HDL were measured. It was found that the administration of 100 mg/kg/day of the extract had reduced the amount of total cholesterol by 45.5% and the administration of 50 mg/kg/day reduced the amount of triglyceride by 48.73%. No significant enhancement was found in the amount of HDL. It was concluded that of Paliurus spina-christi extract can inhibit the enhancement of cholesterol and triglyceride.