Ischemic Preconditioning and Atrial Fibrillation after Coronary Artery Bypass Grafting Surgery

M   Janati; Javad  Kojuri

International Cardiovascular Research Journal

The Official Annually Journal of Cardiovascular Research Center, Shiraz University of Medical Sciences

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Ischemic Preconditioning and Atrial Fibrillation after Coronary Artery Bypass Grafting Surgery

Author(s):

M Janati^1,*,

Javad Kojuri¹

1Cardiovascular Research Center, , Shiraz University of Medical Sciences, Shiraz, Iran

International Cardiovascular Research Journal:Vol. 2, issue 1; e68624

Published online:Mar 31, 2008

Article type:Research Article

Received:Mar 14, 2018

Accepted:Mar 31, 2008

How to Cite:M JanatiJavad KojuriIschemic Preconditioning and Atrial Fibrillation after Coronary Artery Bypass Grafting Surgery.Int Cardiovasc Res J.2(1):e68624.

Abstract

Background: Atrial fibrillation is the most common arrhythmic complication after coronary artery bypass
grafting. Ischemic preconditioning has proved to be a potent endogenous factor in suppressing ischemia- reperfusion
induced arrhythmia.
Patients and Methods: In this prospective study, 101 patients were randomly selected and divided into two
groups including 50 patients with ischemic preconditioning protocol and 51 patients in the control group. Data
were collected from 24 hour electrocardiogram from 1 day before the operation to 3rd post-operative day. Atrial
fibrillation was registered as positive, if it lasted longer than 30 seconds.
Results: The postoperative atrial fibrillation was significantly lower in the ischemic preconditioning group that
was 8% in ischemic preconditioning and 23.52% in control groups (P=0.033). Control group had a longer stay
in intensive care unit and longer mechanical ventilation support.
Conclusion: This study suggests that ischemic preconditioning is a useful prophylactic protocol to decrease the
prevalence of post-cardiac surgery atrial fibrillation.

Keywords

Ischemic Preconditioning

Atrial Fibrillation

Coronary Artery Bypass Grafting

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