The frequency study of anti HLA antibodies of platelet in patients who received blood component in Imam Reza and Taleghani hospitals in Kermanshah

Daryoush  Pourmand; Soraya  Bilvaye; Bahram  Ebrahimi; Mozafar  Aznab; Sahar  Afzali; Shahin  Karimi; Seyed Siamak  Peyambari

Journal of Clinical Research in Paramedical Sciences

The Official Journal of Paramedical School, KUMS

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The frequency study of anti HLA antibodies of platelet in patients who received blood component in Imam Reza and Taleghani hospitals in Kermanshah

Author(s):

Daryoush Pourmand¹,

Soraya Bilvaye^1,*,

Bahram Ebrahimi²,

Mozafar Aznab³,

Sahar Afzali¹,

Shahin Karimi⁴,

Seyed Siamak Peyambari³

1Department of Medical Laboratory Sciences, Paramedicine Faculty, Kermanshah University of Medical Sciences, Kermanshah, Iran

2Blood Transfusion Organization Kermanshah, Kermanshah, Iran

3Department of Oncology, Taleghani Hospital, Kermanshah, Iran

4Department of Oncology, Imam Reza Hospital, Kermanshah, Iran

Journal of Clinical Research in Paramedical Sciences:Vol. 4, issue 1; e81959

Published online:May 17, 2015

Article type:Brief Report

Received:Nov 12, 2014

Accepted:Mar 25, 2015

How to Cite:Pourmand D, Bilvaye S, Ebrahimi B, Aznab M, Afzali S, et al. The frequency study of anti HLA antibodies of platelet in patients who received blood component in Imam Reza and Taleghani hospitals in Kermanshah.J Clin Res Paramed Sci.2015;4(1):e81959.

Abstract

There are alloantibody in the patient with hematologic disorders like acute leukemia and multiple blood transfusion. These alloantibodies are IgM and IgG antibodies against
alloantigens of platelets like HLA antigen.

Platelets resistant was detected in 2-30% of patients with blood transfusion and in 50% patients case a unsuitable respond to platelet transfusion in patients.

In this descriptive analytic Study anti platlet antibodes were detected by lymphocytotoxicity method in 18 patients that received blood and blood components in Imam Reza and Taleghani hospitals.

Anti HLA antibodies detected in 9 of 18 sample of patients with blood disorder and malignance. The mean of old in samples was 24.5 years.

Anti HLA antibodies were detected in 50% of study patients. There were not significant related in anti HLA antibodies and FFP, platelet rates and times of hospitalization. But between ratty and times of pack cell transfusion and anti HLA antibodies a significant related was seen.

Keywords

Alloantibody

Platelet Alloantigen

lymphocytotoxicity test

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