CHARACTERIZATION AND EVALUATION OF OKRA GUM AS A TABLET BINDER

N Tavakoli; N Ghassemi Dehkordi; R Teimouri; H Hamishehkar

Jundishapur Journal of Natural Pharmaceutical Products

The Official Journal of Ahvaz Jundishapur University of Medical Sciences

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CHARACTERIZATION AND EVALUATION OF OKRA GUM AS A TABLET BINDER

Author(s):

N Tavakoli^1,*,

N Ghassemi Dehkordi²,

R Teimouri²,

H Hamishehkar²

1School of Pharmacy and Pharmaceutical Sciences and Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, tavakoli@pharm.mui.ac.ir, Iran

2School of Pharmacy and Pharmaceutical Sciences and Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Iran

Jundishapur Journal of Natural Pharmaceutical Products:Vol. 3, issue 1; 33-38

Article type:Research Article

Received:Oct 11, 2008

Accepted:Jan 24, 2009

How to Cite:N TavakoliN Ghassemi DehkordiR TeimouriH HamishehkarCHARACTERIZATION AND EVALUATION OF OKRA GUM AS A TABLET BINDER.Jundishapur J Nat Pharm Prod.3(1):33-38.

Abstract

The type and amount of binders decisively influence the characteristics of tablets prepared by wet granulation procedure. Commonly used binders like acacia, gelatin, starch and hydrolyzed starch have natural origin. The aim of this study was to evaluate the effectiveness of a new binder extracted from Hibiscus esculentus (Okra gum) in tabletting. Okra gum was extracted from the pods of Okra fruit by maceration in distilled water followed by filtration of viscous solution as well as precipitation of gum extract by using acetone. To evaluate the binder effectiveness, two models, including a placebo formulation (lactose) and a drug formulation (Acetaminophen, Ibuprofen, and/or Calcium acetate) were evaluated. Granules were prepared by different concentrations (0.5-6 %w/w) of Okra gum and tabletted using a Kilian single punch press. Cornstarch (12.5 % w/w) and P.V.P (22 %w/w) were employed as the standard binders for comparison. The physical properties of the granulates and those of the tablets including disintegration time and dissolution rate were studied. The properties of placebo granulates (bulk and tapped density, granule strength, flowability) as well as those of tablets (hardness, friability, disintegration time) were generally good. Moreover, the physical properties of Ibuprofen and Calcium acetate tablets containing Okra gum showed sufficient hardness, desirable disintegration time and low friability. The percent of drug released after 45 minutes were 15 %, 44 % and 96 % for Acetaminophen, Ibuprofen and Calcium acetate tablets, respectively.

Okra gum produces some tablet formulations with good hardness and friability. However, this binder prolongs the dissolution rate of some slightly soluble drugs and hence may be good candidate for sustained release formulations.

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