The combined effect of laser and oral administration of Iranian propolis extract on skin wound healing in male rats

Nematollah Ghaibi; Mohammad Sofiabadi; Amir Farzam; Mina Homayonizade; Monireh Sadat Afzali Arani

doi:10.22110/jkums.v19i2.2195

Journal of Kermanshah University of Medical Sciences

Peer-reviewed Medical Quarterly

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https://doi.org/10.22110/jkums.v19i2.2195

The combined effect of laser and oral administration of Iranian propolis extract on skin wound healing in male rats

Author(s):

Nematollah Ghaibi¹,

Mohammad Sofiabadi^2,*,

Amir Farzam³,

Mina Homayonizade⁴,

Monireh Sadat Afzali Arani⁴

1Biomedical Technology Development Center, Qazvin University of Medical Sciences, Qazvin, Iran

3Dept. of Pathology, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran

4Dept. of Anesthesiology, School of Paramedical Sciences, Qazvin University of Medical Sciences, Qazvin, Iran

Journal of Kermanshah University of Medical Sciences:Vol. 19, issue 2; e69886

Published online:May 29, 2015

Article type:Research Article

Received:Nov 24, 2014

Accepted:May 19, 2015

How to Cite:Nematollah GhaibiMohammad SofiabadiAmir FarzamMina HomayonizadeMonireh Sadat Afzali AraniThe combined effect of laser and oral administration of Iranian propolis extract on skin wound healing in male rats.J Kermanshah Univ Med Sci.19(2):e69886.https://doi.org/10.22110/jkums.v19i2.2195.

Abstract

Background: To date, a lot of research has been carried out on the effect of medications and surgical methods on the treatment of wounds, but no ideal achievement has been obtained yet. This study was conducted to investigate the single and combined effect of laser and propolis on skin wound healing in male rats.

Methods: 40 Wistar male rats (200-250 g) were divided into 4 groups (n= 10). All animals were anesthetized and sterile skin wound was created by surgical scissors. Control group had no treatment, the second group was treated with laser (10 mW), the third group was treated with oral propolis (100 mg /kg; 3 times /day) and the forth group was treated with both laser and propolis. The wound healing level was measured based on the wound area and urinary hydroxyproline content.

Results: Urinary hydroxyproline content was increased in groups treated with laser, propolis and combined laser and propolis compared to the control group (P<0.01, 0.05 and 0.01, respectively). Also at the end of the treatment period, the wound extent was significantly lower in the laser, propolis, and combined laser and propolis groups than the control (P<0.05, 0.05 and 0.01, respectively). There was no significant difference between treatment groups.

Conclusion: Our results showed that oral administration of propolis or low power laser radiation can increase the wound healing rate.

Keywords

wound healing

low power laser

oral propolis extract

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Search Relations

Author(s):

Nematollah Ghaibi:[PubMed][Scholar]
Mohammad Sofiabadi:[PubMed][Scholar]
Amir Farzam:[PubMed][Scholar]
Mina Homayonizade:[PubMed][Scholar]
Monireh Sadat Afzali Arani:[PubMed][Scholar]