Evaluation of Valerians’ effect on sleep quantity and quality of menopausal women: cross-over clinical trial

Mandana Mirmohammadali; Tahereh Zendehdel-Rakhshandeh; Khosro Sadeghniyat-Haghighi; Soghrat Faghihzadeh; Mahshid Taheri

doi:10.22110/jkums.v17i11.1355

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https://doi.org/10.22110/jkums.v17i11.1355

Evaluation of Valerians’ effect on sleep quantity and quality of menopausal women: cross-over clinical trial

Author(s):

Mandana Mirmohammadali¹,

Tahereh Zendehdel-Rakhshandeh^1,*,

Khosro Sadeghniyat-Haghighi²,

Soghrat Faghihzadeh³,

Mahshid Taheri⁴

1Dept. of Reproductive Health, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran

2Occupational Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran

3Dept. of Biostatistics, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran

4Nursing and Midwifery Care Research Center, Tehran University of Medical Sciences, Tehran, Iran

Journal of Kermanshah University of Medical Sciences:Vol. 17, issue 11; e74306

Published online:Feb 27, 2014

Article type:Research Article

Received:Aug 12, 2013

Accepted:Dec 10, 2013

How to Cite:Mirmohammadali M, Zendehdel-Rakhshandeh T, Sadeghniyat-Haghighi K, Faghihzadeh S, Taheri M. Evaluation of Valerians’ effect on sleep quantity and quality of menopausal women: cross-over clinical trial. J Kermanshah Univ Med Sci. 2014;17(11):e74306. doi: https://doi.org/10.22110/jkums.v17i11.1355

Abstract

Background: Menopause causes poor sleep quality in women, so that great throngs of menopausal women experience menopause-induced sleep disorders. This study was conducted to determine the effects of valerian extract on sleep quantity and quality of postmenopausal women.

Methods: This triple-blind, randomized, cross-over clinical trial was performed on 144 eligible postmenopausal women. Participants were randomly classified into two groups to use either 700 mg valerian extract (group A) or a placebo (group B) for one month. After a 2-week washout period, the treatment regimens were reversed. Sleep quantity and quality were evaluated using Pittsburgh and Insomnia Severity Index (ISI) questionnaires at baseline and after both phases of intervention.

Results: Mean score of Pittsburgh scale was 10.9±3.6 at baseline. Valerian reduced this score to 7.8±3.4 and 7.4±3 at the first and the second phase of intervention, respectively (P<0.001). After the first phase of intervention, ISI score was reduced to 2.87±0.62 in group A (P<0.001). It was reduced to 4.02±0.5 in group B after the second phase of intervention (P<0.001).

Conclusion: Daily consumption of 700 mg valerian improved sleep quantity and quality in postmenopausal women

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Author(s):

Mandana Mirmohammadali:[PubMed][Scholar]
Tahereh Zendehdel-Rakhshandeh:[PubMed][Scholar]
Khosro Sadeghniyat-Haghighi:[PubMed][Scholar]
Soghrat Faghihzadeh:[PubMed][Scholar]
Mahshid Taheri:[PubMed][Scholar]

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Evaluation of Valerians’ effect on sleep quantity and quality of menopausal women: cross-over clinical trial

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