Journal of Kermanshah University of Medical Sciences
Peer-reviewed Medical Quarterly
Outlines
Inhibitory effect of aqueous extract of Echinacea purpurea and Nerium oleander on HSV-1 multiplication
Author(s):
1Dept. of Microbiology, Islamic Azad University, Qom Branch, Qom, Iran
*Corresponding Author: Corresponding author: Maliheh Farahani, Dept. of Microbiology, Islamic Azad University, Qom Branch, Qom, Iran, Tel: +98 861 2241127 Email: [email protected]
Published online:Feb 27, 2014
Article type:Research Article
Received:Sep 11, 2013
Accepted:Dec 24, 2013
How to Cite:Farahani M. Inhibitory effect of aqueous extract of Echinacea purpurea and Nerium oleander on HSV-1 multiplication. J Kermanshah Univ Med Sci. 2014;17(11):e74307. doi: https://doi.org/10.22110/jkums.v17i11.655
Abstract
Background: Treatment of HSV-1 infections with the available chemical drugs may have some problems such as drug resistance and virus latency. Therefore, there is a requirement for new antiherpes drugs in today's world. The present study was carried out to analyze the inhibitory effect of Echinacea purpurea and Nerium oleander plants with ethnomedical background on HSV-1 replication.
Methods: Plants were extracted by decoction method to obtain aqueous extract. These extracts were screened for their cytotoxicity against Hep-2 cell line by CPE (cytopathic effect) assay. Antiviral effect of the plant extracts were determined by the virus cytopathic effect inhibition assay.
Results: Nerium oleander extract had the highest toxicity (>0.1 μg/ml) on Hep-2 cells and Echinacea purpurea extract exhibited significant antiherpes effect at nontoxic concentrations used on the cell lines. Findings indicated that Echinacea purpurea extract inhibited HSV-1 multiplication at concentrations >400 μg/ml.
Conclusion: Echinacea purpurea plant had no any effect on cells at nontoxic concentrations and inhibited HSV-1 multiplication at concentrations >400 μg/ml. Further research is needed to find out the anti herpetic mechanism of this plant.
References
- 1.The references of this article is available on PDF.
Copyright
© 2014, Journal of Kermanshah University of Medical Sciences. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.
Similar Articles
20
Nov
2010
Antileishmanial Effect of Echinacea purpurea Root Extract Cultivated in Iran
Sara Soudi,
Seyed Mahmoud Hashemi,
Ahmad Zavaran Hosseini,
Amir Ghaemi,
Mohammad Asghari Jafarabadi
Soudi S, Hashemi SM, Zavaran Hosseini A, Ghaemi A, Asghari Jafarabadi M. Antileishmanial Effect of Echinacea purpurea Root Extract Cultivated in Iran. Iran J Pharm Res. 2022;6(2):e128324. doi: https://doi.org/10.22037/ijpr.2010.713
15
Nov
2004
Antimicrobial effect of different extracts of Nerium oleander L on standard and clinically isolated microorganism
Hassan Rakhshandah,
MohammadTaher Broshki,
Ali Sadeghian,
Heydar Parsaie
Rakhshandah H, Broshki M, Sadeghian A, Parsaie H. Antimicrobial effect of different extracts of Nerium oleander L on standard and clinically isolated microorganism. koomesh. 2004;6(1):e152031. doi:
4
May
2013
Effects of Echinacea purpurea on Hepatic and Renal Toxicity Induced by Diethylnitrosamine in Rats
Annahita Rezaie,
Ali Fazlara,
Mojtaba Haghi Karamolah,
Ali Shahriari,
Hossein Najaf Zadeh,
Marzieh Pashmforosh
Rezaie A, Fazlara A, Haghi Karamolah M, Shahriari A, Najaf Zadeh H, et al. Effects of Echinacea purpurea on Hepatic and Renal Toxicity Induced by Diethylnitrosamine in Rats. Jundishapur J Nat Pharm Prod. 2013;8(2):60-64. doi: https://doi.org/10.17795/jjnpp-9686
21
Jan
2020
In Vitro Antibacterial and Antifungal Studies of Pulicaria undulate and Echinacea purpurea Extracts in Combination with Nanowires (Ni:FeO(OH)) and Nanoparticles (NiS)
Hanieh Askari,
Mehrorang Ghaedi,
Reza Naghiha,
Amin Salehi
Askari H, Ghaedi M, Naghiha R, Salehi A. In Vitro Antibacterial and Antifungal Studies of Pulicaria undulate and Echinacea purpurea Extracts in Combination with Nanowires (Ni:FeO(OH)) and Nanoparticles (NiS). Jundishapur J Nat Pharm Prod. 2020;15(2):e64358. doi: https://doi.org/10.5812/jjnpp.64358
20
Nov
2010
Antifungal Effect of Echinophora Platyloba' s Extract against Candida albicans
Majid Avijgan,
Massoud Hafizi,
Mehdi Saadat,
Mohammad Ali Nilforoushzadeh
Avijgan M, Hafizi M, Saadat M, Nilforoushzadeh MA. Antifungal Effect of Echinophora Platyloba' s Extract against Candida albicans. Iran J Pharm Res. 2022;5(4):e128301. doi: https://doi.org/10.22037/ijpr.2010.691
Download PDF321.38 KB
Crossmark
Checking
Comments
Number of Comments:0Cited by
- Scopus by DOI: 0
Last Update: 1 week ago
- Scopus by Title: 0
Last Update: 1 week ago
- Scopus by Title (Ref): 0
Last Update: 1 week ago
- CrossRef: 0
Last Update: 19 hours ago
Ordering Reprints
Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC
Search Relations
Related Articles