Journal of Kermanshah University of Medical Sciences
Peer-reviewed Medical Quarterly
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The association between glutathione s-transfrases T1, M1, and P1 polymorphisms with end stage renal disease
Author(s):
1Dept. of Biochemistry, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
2Kidney Transplantation Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
*Corresponding Author: Corresponding author: Ali Aidy, Dept. of Biochemistry, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran, Tel: +98 9187697906 Email: [email protected]
Published online:Nov 29, 2013
Article type:Research Article
Received:Apr 13, 2013
Accepted:Sep 10, 2013
How to Cite:Nomani H, Aidy A, Vaisi Raygani A, HaghNazari L, Reissi D, et al. The association between glutathione s-transfrases T1, M1, and P1 polymorphisms with end stage renal disease. J Kermanshah Univ Med Sci. 2013;17(8):e74390. doi:
Abstract
Background: End stage renal disease or ESRD is a progressive and irreversible deterioration in renal function in which the body loses ability to maintain metabolical balance, fluid and electrolytes. Glutathione s-transfrases (GSTs) are members of multigenic family which have essential role as an antioxidant in the cells. In this study, the polymorphism of GST, T1, M1 & P in ESRD patients were compared with those of control groups to determine the possible relationship between polymorphism of these enzymes and ESRD.
Methods: 136 of ESRD patients as experimental and 137 of healthy individuals as control group were examined. The GST T1 & M1 genotypes were determined in all individuals with multiplex- PCR and GST P1 polymorphism was determined with PCR-RFLP.
Results: The distribution of GSTT1& M1 of T1⁺-M1⁺(wild), T1⁺-M1¯, T1¯-M1⁺and T1¯-M1¯(null) genotypes in control group were 45(32.8%), 40(29.2%), 28(20.4%) and 24(17.5%) and in experimental group were17(12.8%), 46(34.6%), 21(15.8%) and 49(36.8%) respectively (P<0.001).
Conclusion: As the reduction of GST T1⁺-M1⁺ (wild) was observed with more frequency in patients with ESRD compared to control group (12.8%vs.32.8%), this genotype can be associated with the risk of ESRD.
References
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Copyright
© 2013, Journal of Kermanshah University of Medical Sciences. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.
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