Low dose oral theophylline effects on HS-CRP in stable COPD patients

Naseh Sigari; Vahid Yousefinejad; Jamal Seidi

Journal of Kermanshah University of Medical Sciences

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Low dose oral theophylline effects on HS-CRP in stable COPD patients

Author(s):

Naseh Sigari^1,*,

Vahid Yousefinejad²,

Jamal Seidi³

1Dept. of Internal Medicine, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran

2Dept. of Forensic Medicine, Tehran University of Medical Sciences, Tehran, Iran

3Dept. of Operating Room, School of Para medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran

Journal of Kermanshah University of Medical Sciences:Vol. 15, issue 4; e79285

Published online:Nov 19, 2011

Article type:Research Article

Received:Jul 23, 2010

Accepted:Dec 14, 2010

How to Cite:Sigari N, Yousefinejad V, Seidi J, Low dose oral theophylline effects on HS-CRP in stable COPD patients.J Kermanshah Univ Med Sci.2011;15(4):e79285.

Abstract

Background: Low dose theophylline may have some anti-inflammatory effects on COPD patients. This study was conducted to determine the effect of oral low dose theophylline on serum CRP level in patients with stable COPD.

Methods: In this double blind randomized clinical trail study, 50 patients (25 in experimental and 25 in placebo group) were enrolled into the study by randomized blocking method. Serum HS-CRP using ELISA method was measured before and after the study. Data was analyzed using t-test and paired t-test.

Results: There was no significant difference in gender, age, smoking and spirometry variables before study between two groups. Serum HS-CRP level remained the same between two groups before and after the intervention.

Conclusion: More studies with large sample size needed to find anti-inflammatory effect of theophylline on macrophages and neutrophils and their derivative inflammatory materials in COPD patients.

Keywords

chronic obstructive pulmonary disease (COPD)

HS-CRP

theophylline

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