Evaluation of the relationship between WBC, HS.CRP and secondary pulmonary hypertension in patients with COPD

Khalil Ansarin; Farid Rashidi; Mohammad Reza Ghaffari; Hossein Namdar; Akbar Sharifi

doi:10.22110/jkums.v17i10.1213

Journal of Kermanshah University of Medical Sciences

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https://doi.org/10.22110/jkums.v17i10.1213

Evaluation of the relationship between WBC, HS.CRP and secondary pulmonary hypertension in patients with COPD

Author(s):

Khalil Ansarin¹,

Farid Rashidi^2,*,

Mohammad Reza Ghaffari¹,

Hossein Namdar³,

Akbar Sharifi¹

1Dept. of Internal Medicine, Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

2Dept. of Internal Medicine, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran

3Dept. of Cardiology, Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Journal of Kermanshah University of Medical Sciences:Vol. 17, issue 10; e74331

Published online:Jan 29, 2014

Article type:Research Article

Received:Jun 10, 2013

Accepted:Oct 29, 2013

How to Cite:Ansarin K, Rashidi F, Ghaffari MR, Namdar H, Sharifi A. Evaluation of the relationship between WBC, HS.CRP and secondary pulmonary hypertension in patients with COPD. J Kermanshah Univ Med Sci. 2014;17(10):e74331. doi: https://doi.org/10.22110/jkums.v17i10.1213

Abstract

Background: Inflammatory mechanisms appear to play a major role in pathogenesis of various types of pulmonary hypertension such as idiopatic PAH (iPAH). Although inflammatory factors such as IL6 and TNFa play an important role in IPAH, there is limited information about the relationship between acute phase reactants and pulmonary hypertension occurring secondary to pulmonary diseases such as chronic obstructive pulmonary diseases (COPD).

Methods: This cross-sectional study was carried out on 94 patients with COPD. Patients with a recent history of systemic corticosteroid use, infection, trauma or surgery, and gastrointestinal bleeding were excluded. Body plethysmography and transthoracic echocardiography were performed. Blood samples were taken from all patients and sent for complete blood count (CBC) and hsCRP tests.

Results: Twenty patients (28.6%) had pulmonary hypertension. There was a significant difference between the mean of WBC in patients with and without pulmonary hypertension (8505 mic/lit vs. 7044 mic/lit) (p=0.04). There was also a significant difference between the hs.CRP in patients with and without pulmonary hypertension (8.8pg/ml vs. 4.07pg/ml) (p=0.032). After adjustment of age, sex, serum hemoglobin, hematocrit, O2sat, FEV1 and FVC, the relationship between the IL6, white blood cell count, HS.CRP and pulmonary hypertension remained significant (p=0.018, p=0.022).

Conclusion: Inflammatory factors such as white blood cell and HS.CRP are independent risk factors of pulmonary hypertension in COPD patients.

Keywords

COPD

pulmonary hypertension

HS.CRP

WBC

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References

1.
The references of this article is available on PDF.

Relationship between complete blood count indices with the severity of disease in patients with chronic obstructive pulmonary disease

Farhad Malek,

Jafar Alaavi Toussy,

Tayebeh Khajeali

Malek F, Alaavi Toussy J, Khajeali T. Relationship between complete blood count indices with the severity of disease in patients with chronic obstructive pulmonary disease. koomesh. 2015;16(2):e151292. doi:

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Mahnaz Mozdorian,

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Hassan Mehrad-Majd,

Shima Nabavi Mahali

Ahi Forsheh M, Mozdorian M, Ebrahimzadeh F, Rajabian A, Mehrad-Majd H, et al. Chronic Obstructive Pulmonary Disease and Platelet Indices: An Indicator of Disease Severity. Shiraz E-Med J. 2023;24(12):e134919. doi: https://doi.org/10.5812/semj-134919

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Mojgan Ghavami,

Hamid Khederlou,

Seyyed Mojtaba Ghorashi,

Soheila Dabiran,

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Gharibi S, Ghavami M, Khederlou H, Ghorashi SM, Dabiran S, et al. Evaluation of the Correlation of Pulmonary Arterial Hypertension (PAH) with the Pulmonary Artery Trunk Diameter and Serum Level of N-Terminal Pro B-Type Natriuretic Peptide (NT-proBNP) in Patients with PAH. I J Radiol. 2023;20(2):e133022. doi: https://doi.org/10.5812/iranjradiol-133022

7

Feb

2021

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Cuihua Bai,

Huandong Tian

Bai C, Tian H. Subclinical Hepatitis C Virus Infection in Patients with Chronic Obstructive Pulmonary Disease: Evidence from a Cross-Sectional Multicenter Observation Study. Jundishapur J Microbiol. 2020;13(11):e109352. doi: https://doi.org/10.5812/jjm.109352

20

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Liang Wang,

Shimin Zheng,

Long-Yang Wu

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Author(s):

Khalil Ansarin:[PubMed][Scholar]
Farid Rashidi:[PubMed][Scholar]
Mohammad Reza Ghaffari:[PubMed][Scholar]
Hossein Namdar:[PubMed][Scholar]
Akbar Sharifi:[PubMed][Scholar]

Peer-reviewed Medical Quarterly

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Evaluation of the relationship between WBC, HS.CRP and secondary pulmonary hypertension in patients with COPD

Abstract

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References

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