Therapeutic Effect of Ferulago angulata Extract on Reproductive Parameters and serum testosterone levels in Diabetic Male Rats

Glavizh Rostami Nassab; Somayeh Bohlouli; Ali Ghanbari

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Therapeutic Effect of Ferulago angulata Extract on Reproductive Parameters and serum testosterone levels in Diabetic Male Rats

Author(s):

Glavizh Rostami Nassab¹,

Somayeh Bohlouli^2,*,

Ali Ghanbari

³

1Department of Biology, Hamedan branch, Islamic Azad University, Hamedan, Iran

2Department of veterinary, College of Agriculture, Kermanshah Branch, Islamic Azad University, Kermanshah, Iran

3Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

Journal of Reports in Pharmaceutical Sciences:Vol. 7, issue 1; 1-8

Published online:Oct 11, 2017

Article type:Research Article

Received:Aug 15, 2017

Accepted:Sep 20, 2017

How to Cite:Glavizh Rostami NassabSomayeh BohlouliAli GhanbariTherapeutic Effect of Ferulago angulata Extract on Reproductive Parameters and serum testosterone levels in Diabetic Male Rats.J Rep Pharm Sci.7(1):e147594.

Abstract

Diabetes is an important metabolic disease inducing different effects on body organs, especially reproductive system. Increased oxidative stress and antioxidant capacity changed in diabetes induce infertility and decrease the sperm parameters. This study was to evaluate the therapeutic effects of hydro alcoholic extract of Ferulago angulata on reproductive parameters in diabetic male rats. In this experimental study, we used 30 male Wistar rats (230- 250g) with an average age of 10 weeks. A total of 24 rats were made diabetes type I by 40 mg/kg streptozotosin. Animals were divided into 5 groups of control, diabetic, and diabetic+ Ferulago angulata extract (100, 200 and 400mg/kg). Sperm parameters, serum testosterone level, seminiferous tubules diameter, and germ line epithelium maturity were assayed at the end of study. Data were analyzed by one‐way ANOVA test and P<0.05 was considered statistically significant. Our results showed serum testosterone level and sperm parameters, including count, viability, progressive motility, and normal morphology as well as seminiferous tubules diameter and germ line epithelium maturity of diabetic male rats increased at 200 and 400 mg/kg doses of Ferulago angulata extract (P<0.05). The hydroalcoholic extract of Ferulago angulata, an herbal plant with abundant antioxidants, improved the quality of sperm and reproductive parameters in diabetic male rats.

Keywords

Diabetes

Ferulago Angulata

Reproductive Parameters

Rat

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