Effects of chronic administration of cyanidin-3-glucoside on serum glucose and lipids in an experimental model of streptozotocin-diabetic rats

Sima Nasri; Mehrdad Roghani; Tourandokht BalochNezhadMojarad; Tahereh Rabani; Mahboubeh Blordi

Koomesh

Journal of Semnan University of Medical Sciences

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Effects of chronic administration of cyanidin-3-glucoside on serum glucose and lipids in an experimental model of streptozotocin-diabetic rats

Author(s):

Sima Nasri,

Mehrdad Roghani

^,*,

Tourandokht BalochNezhadMojarad,

Tahereh Rabani,

Mahboubeh Blordi

Koomesh:Vol. 12, issue 1; 72-78

Published online:Sep 25, 2010

Article type:Research Article

Received:Jun 23, 2010

Accepted:Jul 13, 2010

How to Cite:Sima NasriMehrdad RoghaniTourandokht BalochNezhadMojaradTahereh RabaniMahboubeh BlordiEffects of chronic administration of cyanidin-3-glucoside on serum glucose and lipids in an experimental model of streptozotocin-diabetic rats.koomesh.12(1):e152438.

Abstract

Introduction: Reduction of serum glucose and lipids in diabetic patients using medicinal plants and their effective substances is clinically very important. Given the anti-diabetic potential of cyanidin-3-glucoside in type II diabetes, this study was designed to investigate the effect of chronic administration of cyanidin-3-glucoside on serum glucose and lipids in experimental streptozotocin (STZ) model of diabetes mellitus in rats. Materials and Methods: Diabetes was induced by STZ at a dose of 60mg/kg (i.p) in the adult male rats. Systemic administration of cyanidin-3-glucoside (10 mg/kg) was started one week after induction of diabetes and lasted for two months. The corresponding control groups received appropriate treatments. Serum glucose and lipids levels were measured before and at 4th and 8th weeks after diabetes induction. Results: There was significant increases in serum glucose levels in the diabetic rats at 4th and 8th weeks as compared to the before of diabetes induction (p

Keywords

Cyanidin-3-glucoside, Serum glucose, Serum lipids, Diabetes mellitus

سیانیدین-3-گلوکوزید، گلوکز سرم، لیپید های سرم، دیابت قندی

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