Ibuprofen, is a widely used nonsteroidal anti-inflammatory drug (NSAID). Here, we reported a rare adverse effect of ibuprofen as ibuprofen related skin rash with swelling lips. The case was diagnosed on the present illness and follow up. This is a rare adverse effect of ibuprofen with the incidence less than 0.1 %. The awareness of the physician to this widely used drug on its rare adverse effect is necessary.
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