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Zahedan Journal of Research in Medical Sciences
The Official Journal of Zahedan University of Medical Sciences
e-ISSN 2383-2894
Outline
The Survey of Serum Trace Element Profiles in Down's Syndrome
Authors
1Environmental Laboratory, Nuclear Science s & Technology Research Institute, Faculty Nuclear Science Research, Atomic Energy Organization of Iran , Tehran, Iran
2Environmental Laboratory, Nuclear Science s & Technology Research Institute, Faculty Nuclear Science Research, Atomic Energy Organization of Iran, Tehran, Iran
*Corresponding Author: Environmental Laboratory, Nuclear Science s & Technology Research Institute, Faculty Nuclear Science Research, Atomic Energy Organization of Iran, Tehran, Iran Email: [email protected]
Zahedan Journal of Research in Medical Sciences:Vol. 16, issue 6
Published online:Jul 11, 2012
Article type:Brief Report
Received:Jun 19, 2012
Accepted:Nov 11, 2012
How to Cite:Kupai L, Sajadi F, Farzin L. The Survey of Serum Trace Element Profiles in Down's Syndrome. Zahedan J Res Med Sci. 2014;16(6):. doi:
Abstract
Background: Immunological, endocrinological, haematological and neurological abnormalities are relatively common in people with Down's syndrome (DS). Zinc (Zn), copper (Cu), selenium (Se) and manganese (Mn) are elements that act in the maintenance of normal function of these systems. The present study aimed to evaluate the concentration of these elements on DS symptoms.
Materials and Methods: This case-control study was done from April to October 2011. Serum trace elements including Zn, Cu, Se and Mn were determined by using atomic absorption spectrometry (AAS) in 56 patients with DS and 60 healthy subjects.
Results: There was no significant difference in the values of Cu and Se between two groups (p>0.05). While, Zn and Mn levels were found to be significantly decreased in patients with DS compared to the control group (p<0.01 and p<0.001, respectively).
Conclusion: Results of this study indicate zinc and manganese deficiency in more than 60% of DS patients. Some of the problems experienced by people with DS may be due to changed level of these trace elements.
References
- 1.Refrences are available in PDF.
Copyright
© 2014, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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