Comparative Study of Sedative and Anxiolytic Effects of Herbal Extracts of Hypericum perforatum with Nardostachys jatamansi in Rats

Ali  Rezaei; Mehrdad Pashazadeh; Mahdi  Pashazadeh; Sajad Moghadam

Zahedan Journal of Research in Medical Sciences

The Official Journal of Zahedan University of Medical Sciences

Current Issue All Issues In Press Articles Accepted Manuscripts Search

Journal Information Boards and Committees Indexing and Listing Sources Journal Metrics Open Peer Review (OPR)Publication Ethics and Malpractice Statement Contact Us Support Reviewer and AE Registration Form

APC

Authors Guide Submit Manuscript

Comparative Study of Sedative and Anxiolytic Effects of Herbal Extracts of Hypericum perforatum with Nardostachys jatamansi in Rats

Author(s):

Ali Rezaei^1,*,

Mehrdad Pashazadeh²,

Mahdi Pashazadeh³,

Sajad Moghadam⁴

1Department of Clinical Sciences, Tabr iz Branch, Islamic Azad University, Tabriz, Iran

2Ahar, Andorra

3General Physician , Tabri z Branch, Islamic Azad University, Tabriz, Andorra

4Student of Biology , Ahar Branch , Islamic A zad University, Ahar, Iran

Zahedan Journal of Research in Medical Sciences:Vol. 16, issue 3; 40-43

Published online:Apr 28, 2013

Article type:Research Article

Received:Sep 02, 2012

Accepted:Nov 22, 2012

How to Cite:Ali RezaeiMehrdad PashazadehMahdi PashazadehSajad MoghadamComparative Study of Sedative and Anxiolytic Effects of Herbal Extracts of Hypericum perforatum with Nardostachys jatamansi in Rats.Zahedan J Res Med Sci.16(3):40-43.

Abstract

Background: Nardostachys and hypericum due to the effects of sedation, anticonvulsant, analgesic and anti-depressants has especial place in traditional medicine. Principal component and the alkaloid extract of valerian and isovalerate, valeric acid and the extract of hypericum is hypersin and hyperforin.

Materials and Methods: We conducted this study, valerian rhizome by chloroform: methanol (70:30) was extracted in order to obtain total extract produced the N-hexane and studied chemically have been took by Gc-Ms. Hydro-alcoholic extract of aerial valerian tea was prepared for study. In order to study the comparative effects of soothing extracts of valerian and hypericum in different groups of female rat extract of valerian with doses of 100 mg/kg, 200 mg/kg, 400 mg/kg, and extracts of hypericum with a dose of 250 mg/kg, 500 mg/kg and DMSO (control) with the same volume of 15 minutes prior to the assessment of sedative and sleep (sleep duration induced with ketamine dose and 40 mg/kg were injected intraperitoneally).

Results: The results indicate a significant increase in sleep time induced by ketamine in the treatment groups with high and low doses of valerian extracts and the hypericum is significant at the 0.01 level.

Conclusions: The results show that the extract of valerian in the dose of 200 mg/kg in compress of dose of hypericum 500 mg/kg contains the significant anesthetic effects.

Keywords

Fulltext

Fulltext is availale in the PDF.

References

1.
Refrences are available in PDF.

comments