Effect of Biebersteinia Multifida DC. Root Extract on Cholesterol in Mice

shahrzad khakpour; Meisam Akhlaghdoust; Sara Naimi; S. Mohammad-Javad Mirlohi; Media Abedian; Nazilla Sadat Seyed-Forootan; Fatemeh Foroughi

Zahedan Journal of Research in Medical Sciences

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Effect of Biebersteinia Multifida DC. Root Extract on Cholesterol in Mice

Author(s):

shahrzad khakpour^1,*,

Meisam Akhlaghdoust²,

Sara Naimi²,

S. Mohammad-Javad Mirlohi²,

Media Abedian²,

Nazilla Sadat Seyed-Forootan²,

Fatemeh Foroughi²

1Department of Physiology, Medical Sciences Research Center, Islamic Azad University, Tehran Medical Branch, Tehran, Iran

2Medical Students Research Committee, Islamic Azad University, Tehran Medical Branch, Tehran, Iran

Zahedan Journal of Research in Medical Sciences:Vol. 15, issue 11; e92804

Published online:Feb 02, 2013

Article type:Research Article

Received:Oct 09, 2012

Accepted:Jan 23, 2013

How to Cite:shahrzad khakpourMeisam AkhlaghdoustSara NaimiS. Mohammad-Javad MirlohiMedia AbedianNazilla Sadat Seyed-ForootanFatemeh Foroughiet al.Effect of Biebersteinia Multifida DC. Root Extract on Cholesterol in Mice.Zahedan J Res Med Sci.15(11):e92804.

Abstract

Background : Hypercholesterolemia and atherosclerosis are the most common causes of mortality and disability, especially in developed countries. The aim of this research was to evaluate the effect of Biebersteina multifida DC. root extract on HDL and LDL blood level.
Materials and Methods : In this experimental study, 35 male Balb/c mice were randomly divided in five groups such control, sham, and experimental groups which received Biebersteina multifida DC. root extract with the doses of 4, 5 and 10 mg/kg three last groups were daily fed orally, for thirty days. HDL and LDL blood serum levels were measured, in the last day and compared with control and sham groups.
Results : The results after 30 days gavage of 4, 5 and 10 mg/kg of Biebersteinia Multifida DC. root extract showed that the root extract decrease of LDL level significantly. The doses of 4, 5 mg/kg of the root extract were the effective dose in decreasing the serum HDL level. However, 10 mg/kg dose of root extract has no significant effect on HDL level in comparison with control and sham groups. 10 mg/kg of root extract had the maximum effect on reducing LDL level.
Conclusion : According to this study, it is suggested that the root extract of Biebersteinia multifida DC. can be efficient to reduce the level of HDL and LDL in blood serum.

Keywords

Bibersteinia multifida DC.

HDL

LDL

Mice

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