Bisphenol-A Induces Oxidative Damage in the Liver of Chicken Embryos

Soraya Gharibi; parisa sadighara; Tahereh Mohajerfar; Ramin Mazaherinezhad-Fard; Tahereh Farkhondeh

Zahedan Journal of Research in Medical Sciences

The Official Journal of Zahedan University of Medical Sciences

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Bisphenol-A Induces Oxidative Damage in the Liver of Chicken Embryos

Author(s):

Soraya Gharibi¹,

parisa sadighara²,

Tahereh Mohajerfar¹,

Ramin Mazaherinezhad-Fard³,

Tahereh Farkhondeh^4,*

1Academic Center for Education, Culture and Research, University of Tehran, Tehran, Iran

2Department of Environmental Health, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iran

3Rastegar Reference Laboratory, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran

4Department of Environmental Health, Food Safety Division, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Zahedan Journal of Research in Medical Sciences:Vol. 15, issue 10; e92817

Published online:Mar 12, 2013

Article type:Research Article

Received:Jan 05, 2012

Accepted:Oct 24, 2012

How to Cite:Soraya Gharibiparisa sadigharaTahereh MohajerfarRamin Mazaherinezhad-FardTahereh FarkhondehBisphenol-A Induces Oxidative Damage in the Liver of Chicken Embryos.Zahedan J Res Med Sci.15(10):e92817.

Abstract

Background : Oxidative stress mechanisms are involved in the embryotoxicity. The objective of this study was to assess hepatotoxicity of bisphenol-A (BPA) in chicken embryos.
Materials and Methods : Fertile eggs were randomly divided into 4 groups three experimental and one control groups, (N=15, for each group). Embryos were administered 50, 100 and 200 PPM BPA, and incubated for 48 h at 37°C with a relative humidity of 63%. The experiment was terminated on day 20 of incubation. Then, the embryos were decapitated and livers of embryos were collected for biochemical analysis. The total antioxidant capacity, malondialdehyde (MDA), glutathione (GSH), carotenoid and total protein levels were measured by spectrophotometer.
Results : The result of the present study indicated that the levels of total antioxidant in the livers of embryos exposed to 200 PPM BPA were higher than control and other groups, as well as the levels of MDA compared to control group (p<0.05). The levels of GSH, total carotenoids and total protein were higher in all groups exposed to BPA than control group (p<0.05). In addition, protein concentration in 200 PPM group was higher than of other groups (p<0.001).
Conclusion : So far, BPA may lead to induce toxic response of oxidative system in liver throughout embryonic period.

Keywords

Bisphenol A

Chicken

Embryos developmental

Toxicity

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