Administration of Cannabinoid Receptor Antagonist into the Ventral Tegmental Area Could Inhibit Conditioned Place Preference Induced by Chemical Stimulation of the Lateral Hypothalamus

Zahra Taslimi; Saeid Yazdi-Ravandi,; Abbas Haghparast

Zahedan Journal of Research in Medical Sciences

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Administration of Cannabinoid Receptor Antagonist into the Ventral Tegmental Area Could Inhibit Conditioned Place Preference Induced by Chemical Stimulation of the Lateral Hypothalamus

Author(s):

Zahra Taslimi¹,

Saeid Yazdi-Ravandi,²,

Abbas Haghparast^1,*

1Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2Young Researchers Club, Rudehen Branch, Islamic Azad University, Rudehen, Iran

Zahedan Journal of Research in Medical Sciences:Vol. 15, issue 7; e92928

Published online:Jan 07, 2013

Article type:Research Article

Received:Feb 02, 2012

Accepted:Jun 09, 2012

How to Cite:Zahra TaslimiSaeid Yazdi-Ravandi,Abbas HaghparastAdministration of Cannabinoid Receptor Antagonist into the Ventral Tegmental Area Could Inhibit Conditioned Place Preference Induced by Chemical Stimulation of the Lateral Hypothalamus.Zahedan J Res Med Sci.15(7):e92928.

Abstract

Background: Orexinergic projection originated from the lateral hypothalamus (LH) to the ventral tegmental area (VTA) has an important role in the acquisition of drug conditioned place preference (CPP). In the present study, we tried to evaluate the effect of LH stimulation on conditioned place preference paradigm and role of CB1 receptors located in the VTA in development of reward-related behaviors in rats. Materials and Methods: One hundred twenty adult male Wistar rats weighing 220-330 g were unilaterally implanted by two separate cannulae into the LH and VTA. The CPP paradigm was done. Results: Our findings showed that unilateral intra-LH administration of carbachol (62.5, 125 and 250 nmol/0.5 μl saline), during conditioning phase, induced CPP in a dose-dependent manner. Additionally, intra-VTA administration of AM251 (5, 25 and 125 nmol/0.3 μl DMSO) as a CB1 receptor antagonist, just 5 min before carbachol during the 3-day conditioning phase, could dose dependently inhibit the development of LH stimulation-induced CPP in the rats. Conclusion: It is supposed that the projection from LH to VTA is involved in LH chemical stimulation-induced CPP and CB1 receptor in the VTA has a modulatory role in this phenomenon.

Keywords

Ventral tegmental area

Lateral hypothalamus

Cannabinoid

CB1 receptor

Conditioned place preference

Rat

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