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Zahedan Journal of Research in Medical Sciences
The Official Journal of Zahedan University of Medical Sciences
e-ISSN 2383-2894
Image Credit:Zahedan J Res Med Sci
Outline
Study of Association between Interleukin 20 Polymorphism (Rs1518108) and Chronic Hepatitis C Infection
Authors
Elham Arbabi-Aval1, S. Reza Mohebbi1,*, Fatemeh Rostami1, Manizheh Habibi1, Mohsen Vahedi2, Shohreh Almasi1, Nastaran Saeedi3, Pedram Azimzadeh1, Mohammad-Reza Zali4
1Department of Viral Hepatitis and Liver Diseases, Research Center for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2Department of Biostatistics and Epidemiology, Research Center for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3Department of Molecular Genetics and Cancer, Research Center for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4Research Center for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
*Corresponding Author: Department of Viral Hepatitis and Liver Diseases, Research Center for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran Email: reza1049@yahoo.com
Published online:Jan 07, 2013
Article type:Research Article
Received:Jul 10, 2011
Accepted:Oct 22, 2012
How to Cite:Arbabi-Aval E, Mohebbi SR, Rostami F, Habibi M, Vahedi M, et al. Study of Association between Interleukin 20 Polymorphism (Rs1518108) and Chronic Hepatitis C Infection. Zahedan J Res Med Sci. 2013;15(7):e92927. doi:
Abstract
Background : Chronic hepatitis C is a major concern for global health as it causes liver problems, cirrhosis and liver cancer. Immune factors have a determinant role in susceptibility to chronic infection or clearance of infection in body. As a defensive agent, cytokines are important factors of immune system, since they can activate immune response or inhibit virus replication directly. The aim of this study is the evaluation of interleukin 20 polymorphism (rs1518108) in hepatitis C patients.
Materials and Methods : This survey was a case–control study. By using PCR-RFLP method, 105 patients and 135 controls were studied randomly. We used SPSS-16 software for statistical analysis.
Results : A significant association was found between polymorphism (rs1518108) of interleukin 20 and hepatitis C patients (p=0.035) (OR=2.283). The incidence of hepatitics C in males was observed five times more than that one females (p=0.01) (OR=5.18). In addition, no significant association between polymorphism of genotypes and liver harms (chronic and cirrhosis) was found in this study (p=0.362).
Conclusion : Our findings show that variants of interleukin 20 polymorphism (rs1518108) in the population of the study are important factors for being affected by hepatitis C. The incidence of heterozygote allele CT was more than of homozygote genotype TT.
Highlights
References
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Copyright
© 2013, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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