Protective effect of turnip root ethanolic extract on early diabetic nephropathy in the rats

Bahram Amouoghli-Tabrizi; Dariush Mohajeri

Zahedan Journal of Research in Medical Sciences

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Protective effect of turnip root ethanolic extract on early diabetic nephropathy in the rats

Author(s):

Bahram Amouoghli-Tabrizi^1,*,

Dariush Mohajeri²

1Department of Clinical Sciences, School of Veterinary Medicine, Islamic Azad University, Tabriz Brunch, Tabriz, Iran

2Department of Pathobiology, School of Veterinary Medicine, Islamic Azad University, Tabriz Brunch, Tabriz, Iran.

Zahedan Journal of Research in Medical Sciences:Vol. 13, issue 6; e93830

Published online:May 26, 2011

Article type:Research Article

Received:Oct 22, 2010

Accepted:Nov 18, 2010

How to Cite:Bahram Amouoghli-TabriziDariush MohajeriProtective effect of turnip root ethanolic extract on early diabetic nephropathy in the rats.Zahedan J Res Med Sci.2011;13(6):e93830.

Abstract

Background: Diabetes mellitus is a metabolic disorder and one of its most important consequences is renal insufficiency. A multitude of herbs has been described for the treatment of diabetes mellitus. The aim of present study was to assess the protective effect of turnip root ethanolic extract (TREE) on early nephropathy in alloxan-induced diabetic rats.

Materials and Method: Eighty male Wistar rats were randomly allocated into 4 equal groups including: healthy rats, normal healthy rats receiving TREE, diabetic rats and diabetic rats receiving TREE. Diabetes was induced by a single injection of alloxan (120 mg/kg i.p). The extract (200 mg/kg) was gavaged to TREE treatment groups daily for 8 weeks. At the end of experiment serum levels of urea, uric acid and creatinine were assessed. The lipid peroxidation product, thiobarbituric acid-reacting substances (TBARS), and activities of superoxide dismutase, catalase and glutathione peroxidase were measured in the renal tissue. Finally, the biochemical findings were matched with histopathological verification. Statistically, the quantitative data obtained, compared among the groups by one-way analysis of variance followed by Tukey post-test. Statistical significance was considered at p<0.05.

Results: In the diabetic rats, TREE significantly decreased the levels of serum biomarkers of renal injury. Furthermore, TREE significantly decreased the lipid peroxidation and elevated the decreased levels of antioxidant enzymes in diabetic rats. Histopathological findings were in agreement with the biochemical findings.

Conclusion: TREE has protective effect on early diabetic nephropathy in the rats with experimentally induced diabetes.

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