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62 resultsUpdated October 25, 2026
2

EFFECTS OF PROLOTHERAPY WITH HYPERTONIC DEXTROSE IN PATIENTS WITH KNEE OSTEOARTHRITIS: A RANDOMIZED CLINICAL TRIAL

Journal of Musculoskeletal Research 27(03) (2024)

Maryam Sahebari; Zahra Mirfeizi; Parisa Noorabadi; Zahra Rezaieyazdi; Mandana Khodashahi; Kamila Hashemzadeh; Zohreh Nobakht; Maliheh Dadgarmoghaddam; Bita Abbasi; Forouzan Amerizadeh; Masoumeh Salari

3

The Diagnosis and Therapy of Degenerative Knee Joint Disease: Expert Consensus from the Chinese Pain Medicine Panel

Pain Research and Management 2018 (2018)

Dong Huang; Yan-Qing Liu; Li-Shuang Liang; Xue-Wu Lin; Tao Song; Zhi-Gang Zhuang; Suo-Liang Wang; Hong-Guang Bao; Lin Wang; Xian-Wei Zhang; Zhi-Gang Cheng; Bao-Lin Duan; Wei-Dong Qiu; Yuan-Chang Xiong; Jin-Feng Liu

4

Efficacy of Intramuscular Injection of Calcitonin on Pain Functional Status of Patients with Knee Osteoarthritis

Anesthesiology and Pain Medicine 13(2) (2023)

Mehrdad Taheri; Faranak Behnaz; Mahshid Ghasemi

6

The effect of intra-articular ozone injection combined with home-based exercise on pain and function in daily living activities of patients with mild to moderate knee osteoarthritis, a randomized double-blinded controlled clinical trial

Journal of Bodywork and Movement Therapies 38 (2024)

Mahshid Nazarieh; Shima Ghannadi; Farzin Halabchi; Faezeh Maleklou; Fatemeh Ejtehadi; Seyedeh Roghayeh Ehsani Kouhikheili; Stefan Kluzek; Zahra Alizadeh

8

Accuracy of Ultrasound Guided Versus Blind Knee Intra-articular Injection for Knee Osteoarthritis Prolotherapy

Journal of Anesthesia & Critical Care: Open Access 5(2) (2016)

Behnam Hosseini

9

Adding Ozone to Dextrose and Somatropin for Intra-articular Knee Prolotherapy: A Randomized Single-Blinded Controlled Trial

Anesthesiology and Pain Medicine 10(5) (2020)

Farnad Imani; Kokab Hejazian; Mohammad-Reza Kazemi; Mahnaz Narimani-Zamanabadi; Khalid M Malik

10

Efficacy of combined ozone and platelet-rich-plasma treatment versus platelet-rich-plasma treatment alone in early stage knee osteoarthritis

Journal of Back and Musculoskeletal Rehabilitation 32(2) (2019)

Bahar Dernek; Fatma Nur Kesiktas

11

Short‐Term Therapeutic Effects of Ozone in the Management of Pain in Knee Osteoarthritis: A Meta‐Analysis

PM&R 11(8) (2019)

Pedro Iván Arias‐Vázquez; Carlos Alfonso Tovilla‐Zárate; Yazmín Hernández‐Díaz; Thelma Beatriz González‐Castro; Isela Esther Juárez‐Rojop; María Lilia López‐Narváez; Deysi Yadira Bermudez‐Ocaña; Hugo Adrián Barjau‐Madrígal; Gabriela Legorreta‐Ramírez

12

Comparing the clinical efficacy of multiple vs. single dose ozone (O2-O3) injections and corticosteroid injection in subacromial impingement syndrome: A prospective, randomized controlled trial with One-Year Follow-Up

Journal of Back and Musculoskeletal Rehabilitation 38(5) (2025)

Mehmet Cenk Turgut; Yavuz Şahbat; Ali Afşar; Aslı Turgut; Muhammed Çağatay Engin; Gonca Sağlam Akkaya

13

Meaningful Effectiveness of Platelet-Rich Plasma in Treating Patients with Osteoarthritis of the Knee

The Journal of the International Society of Physical and Rehabilitation Medicine 2(4) (2019)

Abir Hegazy; Paula Karabelas; Abdulhafez Selim

16

Dextrose Prolotherapy

Physical Medicine and Rehabilitation Clinics of North America 27(4) (2016)

Kenneth Dean Reeves; Regina W.S. Sit; David P. Rabago

17

Ozone Improves Pain, Function and Quality of Life in Patients with Knee Osteoarthritis: A Prospective Quasi-Experimental Before-After Study

Middle East Journal of Rehabilitation and Health 4(1) (2016)

Marcos Edgar Fernández Cuadros; Olga Susana Pérez Moro; María Jesús Albaladejo Florin; José Antonio Mirón Canelo

19

A Systematic Review of Dextrose Prolotherapy for Chronic Musculoskeletal Pain

Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders 9 (2016)

Ross A. Hauser; Johanna B. Lackner; Danielle Steilen-Matias; David K. Harris

20

Efficacy and safety of ozone therapy for knee osteoarthritis: an umbrella review of systematic reviews

Frontiers in Physiology 15 (2024)

Valéria T. S. Lino; Daniel S. Marinho; Nadia C. P. Rodrigues; Carlos A. F. Andrade

22

Prolotherapy for knee osteoarthritis using hypertonic dextrose vs other interventional treatments: systematic review of clinical trials

Advances in Rheumatology 59(1) (2019)

Pedro Iván Arias-Vázquez; Carlos Alfonso Tovilla-Zárate; Blanca Gabriela Legorreta-Ramírez; Wajid Burad Fonz; Dory Magaña-Ricardez; Thelma Beatriz González-Castro; Isela Esther Juárez-Rojop; María Lilia López-Narváez

23

Ozone Injection Therapy Compared with Corticosteroid Injections for Knee Osteoarthritis

European Journal of Medical and Health Sciences 4(6) (2022)

Mustafa Yassin; Muhammad Khatib; Mohamad Eisa; Tomer Gazit; Dror Robinson

24

Dextrose prolotherapy in knee osteoarthritis: A systematic review and meta-analysis

Journal of Clinical Orthopaedics and Trauma 19 (2021)

Tze Chao Wee; Edmund Jin Rui Neo; Yeow Leng Tan

25

Effectiveness of Different Concentrations of Dextrose Prolotherapy in Osteoarthritis Knee: A Double-Blind Randomised Comparative Study

Indian Journal of Physical Medicine and Rehabilitation 32(3) (2022)

Snigdha Mishra; Dileep Kumar; Anil Kumar Gupta; Sudhir Ramkishore Mishra; Ganesh Yadav; Debasish Jena

26

Intra-articular ozone therapy efficiently attenuates pain in knee osteoarthritic subjects: A systematic review and meta-analysis

Complementary Therapies in Medicine 42 (2019)

Ali Noori-Zadeh; Salar Bakhtiyari; Roghayeh Khooz; Karimeh Haghani; Shahram Darabi

27

Demonstrating the effectiveness of Platelet Rich Plasma and Prolotherapy treatments in knee osteoarthritis

Irish Journal of Medical Science (1971 -) 192(1) (2023)

Cansın Medin Ceylan; Tugba Sahbaz; Basak Cigdem Karacay

28

Critical appraisal of the systematic review and meta-analysis of intra-articular ozone therapy efficiency to attenuate pain in knee osteoarthritis

Complementary Therapies in Medicine 54 (2020)

Iván Herrera-Peco; A. Santillan-Garcia; D. Cuesta-Lozano; E. Pastor-Ramon; M. García-Puente; O. Aguirre; J.M. Moran

29

Protective effects of ozone therapy on cartilage degeneration in temporomandibular joint osteoarthritis

Inflammopharmacology 33(9) (2025)

Tássia T. Machado; Ana Carolina S. Machado; Catarine M. Nishijima; Cleverton Roberto de Andrade; Sílvio Roberto Consonni; Lizandra M. de Sousa; Carlos A. Parada; Cláudia H. Tambeli

30

EFFECTIVE NONSURGICAL MANAGEMENT OF EARLY OSTEOARTHRITIS OF THE KNEE JOINT IN A TERTIARY CARE HOSPITAL — A PROSPECTIVE SINGLE-BLIND RANDOMIZED COMPARATIVE STUDY

Journal of Musculoskeletal Research 26(01) (2023)

Mruthyunjaya; Sumith Pal Singh; Srikanth Sundaresh; T. Adarsh

31

Structural and Molecular Effects of Dextrose on Cartilage: A Scoping Review

Current Rheumatology Reviews 22(2) (2026)

Pedro Ivan Arias-Vazquez; Kenneth D. Reeves; Rosa Giannina Castillo-Avila; Gaston A. Topol; Ricardo Quezada-Gonzalez; Pavel Loeza-Magana; Elizabeth Carmona-Diaz; Eduardo De la Cruz-Cano; Daniel Cadena-Sandoval

32

Mechanisms and Clinical Applications of Ozone Therapy in Musculoskeletal and Spinal Disorders: A Comprehensive Review

Ozone: Science & Engineering 48(1) (2026)

Seyed Ahmad Raeissadat; Ali Nazari Nodoushan; Alireza Parhizgar; Elahe Keshavarzi; Davood Khavari Ardestani

33

The Effects of Dextrose Prolotherapy in Symptomatic Knee Osteoarthritis: A Randomized Controlled Study

The Journal of Alternative and Complementary Medicine 26(5) (2020)

Alketa T. Sert; Ekin I. Sen; Sina Esmaeilzadeh; Emel Ozcan

34

Results of Combined, Single-Session Arthrocentesis and Dextrose Prolotherapy for Symptomatic Temporomandibular Joint Syndrome: A Case Series

The Journal of Alternative and Complementary Medicine 23(10) (2017)

Burak Cezairli; Efe Can Sivrikaya; Mehmet Melih Omezli; Ferhat Ayranci; Neslihan Seyhan Cezairli

35

New Chronic Pain Treatments in the Outpatient Setting: Review Article

Current Pain and Headache Reports 20(5) (2016)

R. Grandhe; D. Souzdalnitski; K. Gritsenko

36

A Comparison Between Low-Level Laser Therapy and Intra-articular Ozone Injection in Knee Osteoarthritis Treatment: A Randomized Clinical Trial

Journal of Lasers in Medical Sciences 12(1) (2021)

Solmaz Fakhari; Alireza Pishghahi; Hojjat Pourfathi; Haleh Farzin; Eissa Bilehjani

37

A Comprehensive Update of Prolotherapy in the Management of Osteoarthritis of the Knee

Orthopedic Reviews 14(3) (2022)

Alex Tang Zhao; Cassidy J. Caballero; Linh T. Nguyen; Hunter C. Vienne; Christopher Lee; Alan D. Kaye

38

The effects of ultrasound-guided corticosteroid injection compared to oxygen–ozone (O2–O3) injection in patients with knee osteoarthritis: a randomized controlled trial

Clinical Rheumatology 37(9) (2018)

Arash Babaei-Ghazani; Saeedeh Najarzadeh; Korosh Mansoori; Bijan Forogh; Seyed Pezhman Madani; Safoora Ebadi; Hamid Reza Fadavi; Bina Eftekharsadat

39

Comparison of the Efficacy of Dextrose Prolotherapy and Ozone in Patients with Knee Osteoarthritis: A Randomized Cross-Sectional Study

Applied Sciences 11(21) (2021)

Fatih Baygutalp; Mine Çelik; Muhammet Uğur Öztürk; Ahmet Murat Yayık; Ali Ahıskalıoğlu

40

Eficacia de las infiltraciones con ozono en el tratamiento de la osteoartritis de rodilla vs. otros tratamientos intervencionistas: revisión sistemática de ensayos clínicos

Rehabilitación 53(1) (2019)

P.I. Arias-Vázquez; C.A. Tovilla-Zárate; D.Y. Bermudez-Ocaña; B.G. Legorreta-Ramírez; M.L. López-Narváez

41

The temporal effect of intra-articular ozone injections on pain in knee osteoarthritis

British Medical Bulletin (2019)

Antonio Oliviero; Lorenzo Giordano; Nicola Maffulli

42

Lack of standardization among clinical trials of injection therapies for knee osteoarthritis: a systematic review

The Physician and Sportsmedicine 48(3) (2020)

Bryan M. Saltzman; Rachel M. Frank; Annabelle Davey; Eric J. Cotter; Michael L. Redondo; Neal Naveen; Kevin C. Wang; Brian J. Cole

43

Identification of early response to hypertonic dextrose prolotherapy markers in knee osteoarthritis patients by an inflammation-related cytokine array

Journal of the Chinese Medical Association 85(4) (2022)

Po-Jung Pan; Jia-Chi Wang; Chih-Chun Tsai; Hsing-Chun Kuo

44

Hypertonic glucose in the treatment of low back pain: A randomized clinical trial

Medicine 102(38) (2023)

Jose Alberto Pereira Pires; Ed Carlos Rey Moura; Caio Marcio Barros de Oliveira; Almir Vieira Dibai-Filho; Maria do Desterro Soares Brandão Nascimento; Plinio da Cunha Leal

45

Therapeutic efficacy of intra-articular injection of platelet–rich plasma and ozone therapy in patients with primary knee osteoarthritis

The Egyptian Rheumatologist 41(3) (2019)

Nahla M. Gaballa; Yassir A. Mohammed; Lamiaa M. Kamel; Heba M. Mahgoub

46

Efficacy of Prolotherapy for Osteoarthritis: A Systematic Review

Journal of Rehabilitation Medicine 55 (2023)

Yose Waluyo; Sari Rajwani Artika; Insani Nanda Wahyuni; Andi Muh Aunul Khaliq Gunawan; Ahmad Taufik Fadillah Zainal

47

Effectiveness of intra‑articular ozone injections on outcomes of post‑arthroscopic surgery for knee osteoarthritis

Experimental and Therapeutic Medicine (2018)

Xiangjiang Wang; Guiqing Wang; Chunlei Liu; Daozhang Cai

48

The Efficacy of Ozone Prolotherapy Compared to Intra-Articular Hypertonic Saline Injection in Reducing Pain and Improving the Function of Patients with Knee Osteoarthritis: A Randomized Clinical Trial

Evidence-Based Complementary and Alternative Medicine 2021 (2021)

Hamid reza Farpour; Alireza Ashraf; Seyed Saeed Hosseini; Antonella Fioravanti

49

Proliferative injection therapy for osteoarthritis: a systematic review

International Orthopaedics 41(4) (2017)

Mišo Krstičević; Milka Jerić; Svjetlana Došenović; Antonia Jeličić Kadić; Livia Puljak

50

Ozone Therapy as a Therapeutic Option in Rheumatoid Arthritis with Severe Inflammatory Syndrome

Balneo and PRM Research Journal 17(Vol 17 No 1) (2026)

Raluca Ioana Șerban; Gabriel Florin Răzvan Mogoș; Cezar Mucileanu; Iulian Șerban; Florentina Severin; Mariana Rotariu

51

Prolotherapy for knee osteoarthritis

The Scientific Journal of Al-Azhar Medical Faculty, Girls 3(1) (2019)

Hesham El-Dosoky; Saad M. El Zokm; El Sayed Abd El-Hamid; Yousra Abo State

52

Oxygen–Ozone Therapy for the Treatment of Knee Osteoarthritis: A Systematic Review of Randomized Controlled Trials

Arthroscopy 36(1) (2020)

Cristiano Sconza; Stefano Respizzi; Lorenzo Virelli; Filippo Vandenbulcke; Francesco Iacono; Elizaveta Kon; Berardo Di Matteo

53

Mid-Term Effectiveness of Ozone (O2-O3) Compared to Platelet-Rich Plasma (PRP) in the Management of Knee Osteoarthritis: A Randomized Parallel Controlled Trial

Middle East Journal of Rehabilitation and Health In Press(In Press) (2019)

Marcos Edgar Fernandez-Cuadros; Olga Susana Perez-Moro; Maria Jesus Albaladejo-Florin; Beatriz Entrambasaguas-Estepa; Sandra Alava-Rabasa

55

Effectiveness of intra-articular autologous-conditioned Serum Injection in Knee Osteoarthritis: a meta-analysis Study

Future Science OA 7(9) (2021)

Seyed A Raeissadat; Seyed M Rayegani; Mohammad R Sohrabi; Nafisseh Jafarian; Mohammad N Bahrami

56

EVIDÊNCIAS CLÍNICAS E BENEFÍCIOS DA OZONIOTERAPIA NA PRÁTICA MÉDICA: UMA REVISÃO CRÍTICA FOCADA NO REPARO TECIDUAL, MODULAÇÃO INFLAMATÓRIA E APLICAÇÕES ESTÉTICAS

Revista de Geopolítica 17(5) (2026)

José Dalvo Maia Neto; Greyciane Gomes Capistrano; Ana Livia Lima Alves; Deborah Sales Santiago De Albuquerque; Milena de Lima Cavalcante; Bianca Oliveira Lima; Cicera Marina Pinheiro Leite De Oliveira; Heraldo Simões Ferreira

57

Development of an Experimental Setup for Real-Time In-Line Dissolved Ozone Measurement for Medical Therapy

Ozone: Science & Engineering 44(5) (2022)

Lisa Petani; Lorenz Wührl; Liane Koker; Markus Reischl; Jonas Renz; Ulrich Gengenbach; Christian Pylatiuk

58

Efficacy of intra-articular hypertonic dextrose prolotherapy versus normal saline for knee osteoarthritis: a protocol for a triple-blinded randomized controlled trial

BMC Complementary and Alternative Medicine 18(1) (2018)

Regina Wing Shan Sit; Ricky Wing Keung Wu; Kenneth Dean Reeves; David Rabago; Dicken Cheong Chun Chan; Benjamin Hon Kei Yip; Vincent Chi Ho Chung; Samuel Yeung Shan Wong

59

The time-effect relationship of intra-articular ozone injection for knee osteoarthritis: a systematic review and meta-analysis

Frontiers in Pain Research 7 (2026)

Fengjiao Chen; Yufeng Tao; Jing Deng; Leyi Zhang; Lanlan Yu; Zhuoxi Yang; Yixuan Zhang; Chi Zhang

61

Gonartroz Ağrısında Alternatif Tıp Tedavileri

Arşiv Kaynak Tarama Dergisi 34(3) (2025)

Ahmet Issın

62

Effectiveness, Compliance, and Safety of Dextrose Prolotherapy for Knee Osteoarthritis: A Meta-Analysis and Metaregression of Randomized Controlled Trials

Clinical Rehabilitation 36(6) (2022)

Yi-Wen Chen; Yen-Nung Lin; Hung-Chou Chen; Tsan-Hon Liou; Chun-De Liao; Shih-Wei Huang