Regina Wing Shan Sit; Ricky Wing Keung Wu; David Rabago; Kenneth Dean Reeves; Dicken Cheong Chun Chan; Benjamin Hon Kei Yip; Vincent CH Chung; Samuel Yeung Shan Wong

Prolotherapy for knee osteoarthritis using hypertonic dextrose vs other interventional treatments: systematic review of clinical trials

Revista Brasileira de Reumatologia 59(1) (2019)

Pedro Iván Arias‐Vázquez; Carlos Alfonso Tovilla‐Zárate; Blanca Gabriela Legorreta-Ramírez; Wajid Burad Fonz; Dory Magaña-Ricardez; Thelma Beatriz González‐Castro; Isela Esther Juárez‐Rojop; María Lilia López‐Narváez

Intra-articular ozone therapy efficiently attenuates pain in knee osteoarthritic subjects: A systematic review and meta-analysis

Complementary Therapies in Medicine 42 (2018)

Ali Noori-Zadeh; Salar Bakhtiyari; Roghayeh Khooz; Karimeh Haghani; Shahram Darabi

Dextrose prolotherapy in knee osteoarthritis: A systematic review and meta-analysis

Journal of Clinical Orthopaedics and Trauma 19 (2021)

Tze Chao Wee; Edmund Jin Rui Neo; Yeow Leng Tan

Therapeutic Efficacy of Ozone Injection into the Knee for the Osteoarthritis Patient along with Oral Celecoxib and Glucosamine

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH 11(9) (2017)

Feng Xu

Comparative effectiveness of intra-articular prolotherapy versus peri-articular prolotherapy on pain reduction and improving function in patients with knee osteoarthritis: A randomized clinical trial

Electronic physician 9(11) (2017)

Hamid Reza Farpour; Farzane Fereydooni

The Effects of Dextrose Prolotherapy in Symptomatic Knee Osteoarthritis: A Randomized Controlled Study

The Journal of Alternative and Complementary Medicine 26(5) (2020)

Alketa Toska Sert; Ekin İlke Şen; Sina Esmaeilzadeh; Emel E. Ozcan

Short‐Term Therapeutic Effects of Ozone in the Management of Pain in Knee Osteoarthritis: A Meta‐Analysis

PM&R 11(8) (2019)

Pedro Iván Arias‐Vázquez; Carlos Alfonso Tovilla‐Zárate; Yazmín Hernández‐Díaz; Thelma Beatriz González‐Castro; Isela Esther Juárez‐Rojop; María Lilia López‐Narváez; Deysi Y. Bermudez‐Ocaña; Hugo Adrián Barjau Madrigal; Gabriela Legorreta‐Ramírez

The temporal effect of intra-articular ozone injections on pain in knee osteoarthritis

British Medical Bulletin 132(1) (2019)

Antonio Oliviero; Lorenzo Giordano; Nicola Maffulli

Ozone therapy as an integrating therapeutic in osteoartrosis treatment: a systematic review

Brazilian Journal Of Pain 1(2) (2018)

Ana Paula Anzolin; Charise Dallazem Bertol

Efficacy of combined ozone and platelet-rich-plasma treatment versus platelet-rich-plasma treatment alone in early stage knee osteoarthritis

Journal of Back and Musculoskeletal Rehabilitation 32(2) (2018)

Bahar Dernek; Fatma Nur Kesiktaş

Could Ozone Be Used as a Feasible Future Treatment in Osteoarthritis of the Knee?

Diversity & Equality in Health and Care 13(3) (2018)

Marcos Edgar Fernández‐Cuadros

Regenerative Sports Medicine: Past, Present, and Future (Adapted From the PASSOR Legacy Award Presentation; AAPMR; October 2016)

PM&R 10(10) (2018)

Joanne Borg‐Stein; Hector L. Osoria; Todd Hayano

Effectiveness of intra-articular autologous-conditioned Serum Injection in Knee Osteoarthritis: a meta-analysis Study

Future Science OA 7(9) (2021)

Seyed Ahmad Raeissadat; Seyed Mansoor Rayegani; Mohammad-Reza Sohrabi; Nafisseh Jafarian; Mohamad Hassan Bahrami

A Comprehensive Update of Prolotherapy in the Management of Osteoarthritis of the Knee

Orthopedic Reviews 14(3) (2022)

Alex Zhao; Cassidy J. Caballero; Linh Thuy Nguyen; Hunter C. Vienne; Christopher Lee; Alan D. Kaye

Ultrasound-Guided Pes Anserine Bursitis Injection Choices: Prolotherapy or Oxygen-Ozone or Corticosteroid

American Journal of Physical Medicine & Rehabilitation 103(4) (2023)

Arash Babaei-Ghazani; Bina Eftekharsadat; Hosnieh Soleymanzadeh; Masoumeh ZoghAli

The Diagnosis and Therapy of Degenerative Knee Joint Disease: Expert Consensus from the Chinese Pain Medicine Panel

Pain Research and Management 2018 (2018)

Dong Huang; Yanqing Liu; Lishuang Liang; Xuewu Lin; Tao Song; Zhigang Zhuang; Suo-liang Wang; Hongguang Bao; Lin Wang; Xianwei Zhang; Zhigang Cheng; Bao-Lin Duan; Wei-Dong Qiu; Yuan-Chang Xiong; Jinfeng Liu

Therapeutic efficacy of intra-articular injection of platelet–rich plasma and ozone therapy in patients with primary knee osteoarthritis

The Egyptian Rheumatologist 41(3) (2018)

Nahla M. Gaballa; Yassir A. Mohammed; Lamiaa M. Kamel; Heba M. Mahgoub

Ozonoterapia na Osteoartrose do Joelho: Revisão Sistemática

Acta Médica Portuguesa 31(10) (2018)

Tiago Costa; Santiago Rodrigues-Manica; Carina Alves Lopes; João Lagoas Gomes; José Marona; Sandra Falcão; Jaime Branco

Efficacy of intra-articular hypertonic dextrose prolotherapy versus normal saline for knee osteoarthritis: a protocol for a triple-blinded randomized controlled trial

BMC Complementary and Alternative Medicine 18(1) (2018)

Regina Wing Shan Sit; Ricky Wing Keung Wu; Kenneth Dean Reeves; David Rabago; Dicken Cheong Chun Chan; Benjamin Hon Kei Yip; Vincent CH Chung; Samuel Yeung Shan Wong

Periarticular hypertonic dextrose vs intraarticular hyaluronic acid injections: a comparison of two minimally invasive techniques in the treatment of symptomatic knee osteoarthritis

Open Access Rheumatology Research and Reviews Volume 11 (2019)

Behnam Hosseini; Mehrdad Taheri; Reza Pourroustaei Ardekani; Siamak Moradi; Morteza Kazempour Mofrad

Ozone Improves Pain, Function and Quality of Life in Patients with Knee Osteoarthritis: A Prospective Quasi-Experimental Before-After Study

Middle East Journal of Rehabilitation and Health Studies 4(1) (2016)

Marcos Edgar Fernández‐Cuadros; Olga Susana Pérez-Moro; María Jesús Albaladejo-Florín; José Antonio Mirón Canelo

Ozone therapy for musculoskeletal disorders Current concepts.

Acta bio-medica dell'Ateneo parmense/Acta biomedica 91(4) (2020)

Ibrahim Akkawi

Effectiveness, Compliance, and Safety of Dextrose Prolotherapy for Knee Osteoarthritis: A Meta-Analysis and Metaregression of Randomized Controlled Trials

Clinical Rehabilitation 36(6) (2022)

Yiwen Chen; Yen-Nung Lin; Hung‐Chou Chen; Tsan‐Hon Liou; Chun‐De Liao; Shih‐Wei Huang

Effectiveness of intra‑articular ozone injections on outcomes of post‑arthroscopic surgery for knee osteoarthritis

Experimental and Therapeutic Medicine 15(6) (2018)

Xiangjiang Wang; Guiqing Wang; Chunlei Liu; Daozhang Cai

Identification of early response to hypertonic dextrose prolotherapy markers in knee osteoarthritis patients by an inflammation-related cytokine array

Journal of the Chinese Medical Association 85(4) (2022)

Po-Jung Pan; Jia-Chi Wang; Chih-Chun Tsai; Hsing-Chun Kuo

Lack of standardization among clinical trials of injection therapies for knee osteoarthritis: a systematic review

The Physician and Sportsmedicine 48(3) (2020)

Bryan Michael Saltzman; Rachel M. Frank; Annabelle P. Davey; Eric J. Cotter; Michael L. Redondo; Neal Bhojraj Naveen; Kevin C. Wang; Brian J. Cole

The effect of intra-articular ozone injection combined with home-based exercise on pain and function in daily living activities of patients with mild to moderate knee osteoarthritis, a randomized double-blinded controlled clinical trial

Journal of Bodywork and Movement Therapies 38 (2024)

Mahshid Nazarieh; Shima Ghannadi; Farzin Halabchi; Faezeh Maleklou; Fatemeh Ejtehadi; Seyedeh Roghayeh Ehsani Kouhikheili; Stefan Kluzek; Zahra Alizadeh

Protective effects of ozone therapy on cartilage degeneration in temporomandibular joint osteoarthritis

Inflammopharmacology 33(9) (2025)

Tassia Tillemont Machado; Ana Carolina S. Machado; Catarine Massucato Nishijima; Cléverton Roberto de Andrade; Sílvio Roberto Consonni; Lizandra Maia de Sousa; Carlos Amílcar Parada; Cláudia Herrera Tambeli

Mechanisms and Clinical Applications of Ozone Therapy in Musculoskeletal and Spinal Disorders: A Comprehensive Review

Ozone Science and Engineering 48(1) (2025)

Seyed Ahmad Raeissadat; Ali Nazari Nodoushan; Alireza Parhizgar; Elahe Keshavarzi; Davood Khavari Ardestani

Proliferative injection therapy for osteoarthritis: a systematic review

International Orthopaedics 41(4) (2017)

Mišo Krstičević; Milka Jerić; Svjetlana Došenović; Antonia Jeličić Kadić; Livia Puljak

Results of Combined, Single-Session Arthrocentesis and Dextrose Prolotherapy for Symptomatic Temporomandibular Joint Syndrome: A Case Series

The Journal of Alternative and Complementary Medicine 23(10) (2017)

Burak Cezairli; Efe Can Sivrikaya; Mehmet Melih Ömezli; Ferhat Ayrancı; Neslihan Seyhan Cezairli

Everything old is new again: New developments in prolotherapy

Techniques in Regional Anesthesia and Pain Management 19(1-2) (2015)

Andrea M. Trescot

A Comparison Between Low-Level Laser Therapy and Intra-articular Ozone Injection in Knee Osteoarthritis Treatment: A Randomized Clinical Trial

Journal of lasers in medical sciences 12(1) (2021)

Solmaz Fakhari; Alireza Pishgahi; Hojjat Pourfathi; Haleh Farzin; Eissa Bilehjani

Eficacia de las infiltraciones con ozono en el tratamiento de la osteoartritis de rodilla vs. otros tratamientos intervencionistas: revisión sistemática de ensayos clínicos

Rehabilitación 53(1) (2018)

Pedro Iván Arias‐Vázquez; Carlos Alfonso Tovilla‐Zárate; Deysi Y. Bermudez‐Ocaña; Blanca Gabriela Legorreta-Ramírez; María Lilia López‐Narváez

New Chronic Pain Treatments in the Outpatient Setting: Review Article

Current Pain and Headache Reports 20(5) (2016)

Radhika Grandhe; Dmitri Souzdalnitski; Karina Gritsenko

Adding Ozone to Dextrose and Somatropin for Intra-articular Knee Prolotherapy: A Randomized Single-Blinded Controlled Trial

Anesthesiology and Pain Medicine 10(5) (2020)

Farnad Imani; Kokab Hejazian; Mohammad-Reza Kazemi; Mahnaz Narimani Zamanabadi; Khalid M Malik

Development of an Experimental Setup for Real-Time In-Line Dissolved Ozone Measurement for Medical Therapy

Ozone Science and Engineering 44(5) (2021)

Lisa Petani; Lorenz Wührl; Liane Koker; Markus Reischl; Jonas Renz; Ulrich K. Gengenbach; Christian Pylatiuk

The Efficacy of Ozone Prolotherapy Compared to Intra-Articular Hypertonic Saline Injection in Reducing Pain and Improving the Function of Patients with Knee Osteoarthritis: A Randomized Clinical Trial

Evidence-based Complementary and Alternative Medicine 2021 (2021)

Hamid Reza Farpour; Alireza Ashraf; Seyed Saeed Hosseini

Ameliorative Effects of Prolotherapy on Histomorphology of Tibial Articular Cartilage of Chemically Induced Osteoarthritic Knee Joint in a Rat Model

Journal of College of Physicians And Surgeons Pakistan 33(08) (2023)

Aqsa Zahid; Khadija Qamar; Asima Tabassum; Mehwish Abaid; Muhammad Rizwan Bashir Kiani; Maria Aslam

Hypertonic glucose in the treatment of low back pain: A randomized clinical trial

Medicine 102(38) (2023)

José Alberto Pereira Pires; Ed Carlos Rey Moura; Caio Márcio Barros de Oliveira; Almir Vieira Dibai‐Filho; Maria do Desterro Soares Brandão Nascimento; Plínio da Cunha Leal

Does intra-articular medical ozone therapy applied at different concentrates improve outcomes of temporomandibular joint osteoarthritis? A randomized clinical trial

Journal of Cranio-Maxillofacial Surgery 53(6) (2025)

Songül Cömert Kılıç; Mine Gürsaç Çeli̇k

Comparison of the Efficacy of Dextrose Prolotherapy and Ozone in Patients with Knee Osteoarthritis: A Randomized Cross-Sectional Study

Applied Sciences 11(21) (2021)

Fatih Baygutalp; Mine Çelik; Muhammet Uğur Öztürk; Ahmet Murat Yayık; Ali Ahişkalıoğlu

The Short-term Effect of Consecutive Platelet-rich Plasma Injections on Chronic Pain in Knee Osteoarthritis

Forbes Journal of Medicine 3(2) (2022)

Ülkü Dönmez

Comparing the clinical efficacy of multiple vs. single dose ozone (O2-O3) injections and corticosteroid injection in subacromial impingement syndrome: A prospective, randomized controlled trial with One-Year Follow-Up

Journal of Back and Musculoskeletal Rehabilitation 38(5) (2025)

Mehmet Cenk Turğut; Yavuz Şahbat; Ali Afşar; Aslı Turgut; Muhammed Çağatay Engin; Gonca Sağlam

Accuracy of Ultrasound Guided Versus Blind Knee Intra-articular Injection for Knee Osteoarthritis Prolotherapy

Journal of Anesthesia & Critical Care Open Access 5(2) (2016)

Behnam Hosseini

Mid-Term Effectiveness of Ozone (O2-O3) Compared to Platelet-Rich Plasma (PRP) in the Management of Knee Osteoarthritis: A Randomized Parallel Controlled Trial

Middle East Journal of Rehabilitation and Health Studies In Press(In Press) (2019)

Marcos Edgar Fernández‐Cuadros; Olga Susana Pérez-Moro; María Jesús Albaladejo-Florín; Beatriz Entrambasaguas-Estepa; Sandra Álava-Rabasa

Ozone Therapy in Wound Care

Springer eBooks (2023)

Fabio Sallustio; Marco Fiorentino; Paola Pontrelli; Mariagiovanna Di Chiano; Annalisa Casanova; Nicla Campobasso; Loreto Gesualdo

A Single-Dose Injection of Ozone Is Not an Alternative of Corticosteroid Injection in Shoulder Impingement Syndrome

American Journal of Physical Medicine & Rehabilitation 99(7) (2019)

Murat Kara; Eda Gürçay

Ozone Injection Therapy Compared with Corticosteroid Injections for Knee Osteoarthritis

European Journal of Medical and Health Sciences 4(6) (2022)

Mustafa Yassin; Muhammad Khatib; Mohamad Eisa; Tomer Gazit; Dror Robinson

Structural and Molecular Effects of Dextrose on Cartilage: A Scoping Review

Current Rheumatology Reviews 22(2) (2025)

Pedro Iván Arias‐Vázquez; Kenneth Dean Reeves; Rosa Giannina Castillo-Ávila; Gastón Andrés Topol; Héctor Ricardo Quezada-González; Pavel Loeza Magaña; Elizabeth Carmona Díaz; Eduardo De la Cruz-Cano; Daniel Cadena Sandoval

Ozone Therapy as a Therapeutic Option in Rheumatoid Arthritis with Severe Inflammatory Syndrome

Balneo and PRM Research Journal 17(Vol 17 No 1) (2026)

Raluca Ioana Şerban; Gabriel Florin Răzvan Mogoș; Cezar Mucileanu; Iulian Șerban; Florentina Severin; Mariana Rotariu

Critical appraisal of the systematic review and meta-analysis of intra-articular ozone therapy efficiency to attenuate pain in knee osteoarthritis

Complementary Therapies in Medicine 54 (2019)

Iván Herrera‐Peco; Azucena Santillán García; Daniel Cuesta‐Lozano; Elena Pastor-Ramón; María García‐Puente; Oskia Aguirre; José María Morán

Demonstrating the effectiveness of Platelet Rich Plasma and Prolotherapy treatments in knee osteoarthritis

Irish Journal of Medical Science (1971 -) 192(1) (2022)

Cansın Medin Ceylan; Tuğba Şahbaz; Başak Çiğdem Karaçay

Association between cartilage biomarker level and functional outcome in knee osteoarthritis patients receiving dextrose prolotherapy: a cross-sectional study

Bali Medical Journal 11(3) (2022)

Yose Waluyo; Agussalim Bukhari; Endy Adnan; Sari Rajwani Artika; Ahmad Yasin; Insani Nanda Wahyuni; Budu Budu

Hypertonic Dextrose Injection for The Treatment of a Baker's Cyst

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH 10(2) (2016)

Ferdi Yavuz

Clinical efficacy of lumbar interbody fusion using a channel system combined with ozone therapy for the treatment of central-type L3-L4 lumbar disc herniation

Experimental and Therapeutic Medicine 13(2) (2016)

Yu Wang; Hong Juan Sun; Shuzhen Qin

Ozone or hyaluronic acid in the intra-articular treatment of knee osteoarthritis?

Northwestern Medical Journal 2(3) (2022)

Merve Damla Korkmaz; Ahmet Kıvanç Menekşeoğlu

Comparative efficacy and safety of oral or transdermal opioids in the treatment of knee or hip osteoarthritis: a systematic review and Bayesian network meta-analysis protocol

BMJ Open 8(10) (2018)

Jun Wang; Wang Yin; Hui Zhang; Ming Shian Lu; Weilu Gao; Li Yin; Zongsheng Yin

Meaningful Effectiveness of Platelet-Rich Plasma in Treating Patients with Osteoarthritis of the Knee

The Journal of the International Society of Physical and Rehabilitation Medicine 2(4) (2019)

Abir Hegazy; Paula Karabelas; Abdulhafez Selim

EFFECTIVE NONSURGICAL MANAGEMENT OF EARLY OSTEOARTHRITIS OF THE KNEE JOINT IN A TERTIARY CARE HOSPITAL — A PROSPECTIVE SINGLE-BLIND RANDOMIZED COMPARATIVE STUDY

Journal of Musculoskeletal Research 26(01) (2023)

Mruthyunjaya Mruthyunjaya; Sumith Pal Singh; Srikanth Sundaresh; T. Adarsh

The role of ozone and its potentiating effect on steroids and vesicosupplement injections for knee osteoarthritis

International Journal of Medical Anesthesiology 6(4) (2023)

Yahia Hatem Kazum Al Bayati

Prolotherapy for knee osteoarthritis

The Scientific Journal of Al-Azhar Medical Faculty Girls 3(1) (2019)

Hesham El-Dosoky; Saad M. El Zokm; El Sayed Abd El-Hamid; Yousra Abo State

Lumbar Radiculopathy

Springer eBooks (2019)

Ramsin M Benyamin; William J. Smith; James Lieber; Ricardo Vallejo

Effectiveness of Different Concentrations of Dextrose Prolotherapy in Osteoarthritis Knee: A Double-Blind Randomised Comparative Study

Indian Journal of Physical Medicine and Rehabilitation 32(3) (2022)

Snigdha Mishra; Dileep Kumar; Anil Kumar Gupta; Sudhir Ramkishore Mishra; Ganesh Yadav; Debasish Jena

A retrospective study for the effect of local ozone injection for treatment of musculoskeletal disorders

Medical Science and Discovery (2018)

Emre Ata

Intraarticular Injections of Ozone Gas in Knee Osteoarthritis

Springer eBooks (2020)

Emerito Carlos Rodriguez-Merchan; Hortensia De la Corte‐Rodríguez; Juan Manuel Román-Belmonte

COMPARATIVE OF INTRAARTICULAR INJECTION BETWEEN DEXTROSE PROLOTHERAPY VERSUS TRIAMCINOLONE ACETONIDE IN KNEE OSTEOARTHRITIS

JPHV (Journal of Pain Vertigo and Headache) 1(2) (2020)

Widodo Mardi Santoso; Andhy Indriyono; Badrul Munir; Alidha Nur Rakhman; Machlusil Husna

TRATAMENTO COM OZÔNIO NA ARTRITE REUMATOIDE: UMA REVISÃO SISTEMÁTICA

CADERNOS DE EDUCAÇÃO SAÚDE E FISIOTERAPIA 9(19) (2022)

Felipe Figueiredo Moreira; Ana Paula Santos Tartari; Ivo Ilvan Kerppers; Mário César da Silva Pereira; Angela Dubiela Julik; Patrícia Pacheco Tyski Suckow; Eliane Gonçalves de Jesus Fonseca; Raphaella Rosa Horst Massuqueto; Ana Carolina Dorigoni Bini

Efficacy of Intramuscular Injection of Calcitonin on Pain Functional Status of Patients with Knee Osteoarthritis

Anesthesiology and Pain Medicine 13(2) (2023)

Mehrdad Taheri; Faranak Behnaz; Mahshid Ghasemi

Intra-articular Injection Therapy in Knee Osteoarthropathy: a Narrative Review

Rehabilitation practice and science 2023(2) (2023)

Alan Chang; Yi‐Hsiang Chiu; Chueh‐Hung Wu; Tyng‐Guey Wang

EFFECTS OF PROLOTHERAPY WITH HYPERTONIC DEXTROSE IN PATIENTS WITH KNEE OSTEOARTHRITIS: A RANDOMIZED CLINICAL TRIAL

Journal of Musculoskeletal Research 27(03) (2024)

Maryam Sahebari; Zahra Mirfeizi; Parisa Noorabadi; Zahra Rezaieyazdi; Mandana Khodashahi; Kamila Hashemzadeh; Zohreh Nobakht; Maliheh Dadgarmoghaddam; Bita Abbasi; Forouzan Amerizadeh; Masoumeh Salari

A retrospective study for the effect of local ozone injection for treatment of musculoskeletal disorders

Medical Science and Discovery 5(8) (2018)

Emre Ata

Gonartroz Ağrısında Alternatif Tıp Tedavileri

Arşiv Kaynak Tarama Dergisi 34(3) (2025)

AHMET ISSIN

EVIDÊNCIAS CLÍNICAS E BENEFÍCIOS DA OZONIOTERAPIA NA PRÁTICA MÉDICA: UMA REVISÃO CRÍTICA FOCADA NO REPARO TECIDUAL, MODULAÇÃO INFLAMATÓRIA E APLICAÇÕES ESTÉTICAS

Revista de Geopolítica 17(5) (2026)

José Dalvo Maia Neto; Greyciane Gomes Capistrano; ANA LÍVIA LIMA ALVES; Deborah Sales Santiago De Albuquerque; Milena de Lima Cavalcante; Bianca Oliveira Lima; Cicera Marina Pinheiro Leite De Oliveira; Heraldo Simões Ferreira

The time-effect relationship of intra-articular ozone injection for knee osteoarthritis: a systematic review and meta-analysis

Frontiers in Pain Research 7 (2026)

Fengjiao Chen; Yufeng Tao; Jing Deng; L Y Zhang; Lanlan Yu; Zhuoxi Yang; Yixuan Zhang; Chi Zhang