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19 resultsUpdated August 16, 2026
1

A Cannabinoid Receptor Type 1 (CB1R) Agonist Enhances the Developmental Neurotoxicity of Acetaminophen (Paracetamol)

Toxicological Sciences 166(1) (2018)

Gaëtan Philippot; Stefan Hallgren; Torsten Gordh; Anders Fredriksson; Robert Fredriksson; Henrik Viberg

5

The Ocular Penetration and Intraocular Pressure Lowering Effect of Topical Acetaminophen in the New Zealand White Rabbit

Journal of Ocular Pharmacology and Therapeutics 40(8) (2024)

Sean G. Anderson; David Meyer; Eric H. Decloedt

6

Gestational paracetamol exposure induces core behaviors of neurodevelopmental disorders in infant rats and modifies response to a cannabinoid agonist in females

Neurotoxicology and Teratology 99 (2023)

Rodrigo Moreno Klein; Vanessa Nishikawa Motomura; Juliana Diosti Debiasi; Estefânia Gastaldello Moreira

7

Long-Term Paracetamol Treatment Impairs Cognitive Function and Brain-Derived Neurotrophic Factor in Adult Rat Brain

Scientia Pharmaceutica 91(1) (2023)

Laddawan Lalert; Nutnicha Tantarungsee; Tipthanan Chotipinit; Wilawan Ji-au; Anan Srikiatkhachorn; Supang Maneesri-le Grand

8

Systems pharmacology of hepatic metabolism in zebrafish larvae

Drug Discovery Today: Disease Models 22 (2016)

Rob C. van Wijk; Elke H.J. Krekels; Thomas Hankemeier; Herman P. Spaink; Piet H. van der Graaf

10

Activation of the capsaicin-receptor TRPV1 by the acetaminophen metabolite N -arachidonoylaminophenol results in cytotoxicity

Life Sciences 194 (2018)

Thomas Stueber; Susanne Meyer; Annette Jangra; Axel Hage; Mirjam Eberhardt; Andreas Leffler

13

Acetaminophen inhibits diacylglycerol lipase synthesis of 2-arachidonoyl glycerol: Implications for nociception

Cell Reports Medicine 6(6) (2025)

Michaela Dvorakova; Taryn Bosquez-Berger; Jenna Billingsley; Natalia Murataeva; Taylor Woodward; Emma Leishman; Anaëlle Zimmowitch; Anne Gibson; Jim Wager-Miller; Ruyi Cai; Shangxuan Cai; Tim Ware; Ku-Lung Hsu; Yulong Li; Heather Bradshaw; Ken Mackie; Alex Straiker

14

Human sperm cells can form paracetamol metabolite AM404 that directly interferes with sperm calcium signalling and function through a CatSper-dependent mechanism

Human Reproduction 37(5) (2022)

A Rehfeld; H Frederiksen; R H Rasmussen; A David; J Chaker; B S Nielsen; J E Nielsen; A Juul; N E Skakkebæk; D M Kristensen

15

Paracetamol and ibuprofen in the treatment of pain and fever in children: modern views on the choice of a drug

Meditsinskiy sovet = Medical Council(17) (2023)

I. N. Zakharova; I. V. Berezhnaya; V. V. Pupykina; A. D. Gostyukhina; N. F. Dubovets

16

Pharmacokinetic profile of metabolites by heart-cutting two-dimensional liquid chromatography: A focus on paracetamol analysis

Journal of Chromatography A 1745 (2025)

Ana Ballester-Caudet; Simón Mariño Perea; Diego García-Gómez; José Luis Pérez Pavón; Encarnación Rodríguez-Gonzalo

17

AM404, paracetamol metabolite, prevents prostaglandin synthesis in activated microglia by inhibiting COX activity

Journal of Neuroinflammation 14(1) (2017)

Soraya Wilke Saliba; Ariel R. Marcotegui; Ellen Fortwängler; Johannes Ditrich; Juan Carlos Perazzo; Eduardo Muñoz; Antônio Carlos Pinheiro de Oliveira; Bernd L. Fiebich

18

Transcriptomic signature, bioactivity and safety of a non-hepatotoxic analgesic generating AM404 in the midbrain PAG region

Scientific Reports 14(1) (2024)

Hernan A. Bazan; Surjyadipta Bhattacharjee; Madigan M. Reid; Bokkyoo Jun; Connor Polk; Madeleine Strain; Linsey A. St Pierre; Neehar Desai; Patrick W. Daly; Jessica A. Cucinello-Ragland; Scott Edwards; Javier Recio; Julio Alvarez-Builla; James J. Cai; Nicolas G. Bazan

19

High-Dose Acetaminophen as a Treatment for Cancer

Livers 4(1) (2024)

Jeffrey Wu; Bradley Maller; Rujul Kaul; Andrea Galabow; Allyn Bryan; Alexander Neuwelt