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30 resultsUpdated October 23, 2026
2

An Updated Review on the Metabolite (AM404)-Mediated Central Mechanism of Action of Paracetamol (Acetaminophen): Experimental Evidence and Potential Clinical Impact

Journal of Pain Research Volume 16 (2023)

Christophe Mallet; Jules Alexandre Desmeules; Rassa Pegahi; Alain Eschalier

3

The analgesic paracetamol metabolite AM404 acts peripherally to directly inhibit sodium channels

Proceedings of the National Academy of Sciences 122(23) (2025)

Yossef Maatuf; Yishai Kushnir; Alina Nemirovski; Mariana Ghantous; Ariel Iskimov; Alexander M. Binshtok; Avi Priel

4

AM404, paracetamol metabolite, prevents prostaglandin synthesis in activated microglia by inhibiting COX activity

Journal of Neuroinflammation 14(1) (2017)

Soraya Wilke Saliba; Ariel R. Marcotegui; Ellen Fortwängler; Johannes Ditrich; Juan Carlos Perazzo; Eduardo Muñóz; Antônio Carlos Pinheiro de Oliveira; Bernd L. Fiebich

5

First evidence of the conversion of paracetamol to AM404 in human cerebrospinal fluid

Journal of Pain Research Volume 10 (2017)

Chhaya Sharma; Jamie H Long; Seema Rupani Shah; Junia Rahman; David Ian Perrett; Samir S. Ayoub; Vivek Mehta

6

Systems pharmacology of hepatic metabolism in zebrafish larvae

Drug Discovery Today Disease Models 22 (2016)

Rob Christiaan van Wijk; Elke H. J. Krekels; Thomas Hankemeier; Herman P. Spaink; Piet H. van der Graaf

7

Teratogenic effects induced by paracetamol, ciprofloxacin, and their mixture on Danio rerio embryos: Oxidative stress implications

The Science of The Total Environment 806(Pt 2) (2021)

Jonathan Ricardo Rosas-Ramírez; José Manuel Orozco-Hernández; Gustavo Axel Elizalde-Velázquez; Demetrio Raldúa; Hariz Islas‐Flores; Leobardo Manuel Gómez‐Oliván

8

Human sperm cells can form paracetamol metabolite AM404 that directly interferes with sperm calcium signalling and function through a CatSper-dependent mechanism

Human Reproduction 37(5) (2022)

Anders Rehfeld; Hanne Winther Frederiksen; Rikke Holm Rasmussen; Arthur David; Jade Chaker; Brian Skriver Nielsen; J E Nielsen; Anders Juul; Niels Erik Skakkebæk; David M. Kristensen

9

Gestational paracetamol exposure induces core behaviors of neurodevelopmental disorders in infant rats and modifies response to a cannabinoid agonist in females

Neurotoxicology and Teratology 99 (2023)

Rodrigo Moreno Klein; Vanessa Nishikawa Motomura; Juliana Diosti Debiasi; Estefânia Gastaldello Moreira

10

A Cannabinoid Receptor Type 1 (CB1R) Agonist Enhances the Developmental Neurotoxicity of Acetaminophen (Paracetamol)

Toxicological Sciences 166(1) (2018)

Gaëtan Philippot; Stefan Hallgren; Torsten Gordh; Anders Fredriksson; Robert Fredriksson; Henrik Viberg

11

Mechanism of Action, Kinetics and a Bioactive Metabolites AM404 of Paracetamol

Journal of Clinical Medical Research 01(02) (2020)

Sarbjeet Singh; Mandeep Kaur

12

High-Dose Acetaminophen as a Treatment for Cancer

Livers 4(1) (2024)

Jeffrey J. Wu; Bradley Maller; Rujul Kaul; Andrea Galabow; Allyn Bryan; Alexander J. Neuwelt

13

Acetaminophen inhibits diacylglycerol lipase synthesis of 2-arachidonoyl glycerol: Implications for nociception

Cell Reports Medicine 6(6) (2025)

Michaela Dvořáková; Taryn Bosquez-Berger; Jenna Billingsley; Natalia Murataeva; Taylor J. Woodward; Emma Leishman; Anaëlle Zimmowitch; Anne Gibson; Jim Wager‐Miller; Ruyi Cai; Shangxuan Cai; Tim Ware; Ku‐Lung Hsu; Yulong Li; Heather B. Bradshaw; Ken Mackie; Alex J. Straiker

14

Activation of the capsaicin-receptor TRPV1 by the acetaminophen metabolite N -arachidonoylaminophenol results in cytotoxicity

Life Sciences 194 (2017)

Thomas Stueber; SUSANNE R. MEYER; Annette Jangra; Axel Hage; Mirjam Jeanette Eberhardt; Andreas Leffler

16

Paracetamol: Update on its Analgesic Mechanism of Action

InTech eBooks (2017)

Christophe Mallet; Alain Eschalier; Laurence Daulhac

17

Long-Term Paracetamol Treatment Impairs Cognitive Function and Brain-Derived Neurotrophic Factor in Adult Rat Brain

Scientia Pharmaceutica 91(1) (2023)

Laddawan Lalert; Nutnicha Tantarungsee; Tipthanan Chotipinit; Wilawan Ji‐au; Anan Srikiatkhachorn; Supang Maneesri-le Grand

18

Transcriptomic signature, bioactivity and safety of a non-hepatotoxic analgesic generating AM404 in the midbrain PAG region

Scientific Reports 14(1) (2024)

Hernan A. Bazán; Surjyadipta Bhattacharjee; Madigan M. Reid; Bokkyoo Jun; Connor Polk; Madeleine Strain; Linsey St Pierre; Neehar N Desai; Philip J. Daly; Jessica A. Cucinello‐Ragland; Scott Edwards; Javier Recio; Julio Álvarez‐Buílla; James J. Cai; Nicolas Guillermo Bazan

20

Effect of Paracetamol on postoperative pain in children undergoing strabismus surgery under Desflurane anesthesia

Perioperative Care and Operating Room Management 24 (2021)

Mehdi Rezaee; Zahra Ebrahim Soltani; Alireza Takzare; Abolfazl Badripour; Mehrdad Goudarzi; Soroosh Alizade

21

Paracetamol and ibuprofen in the treatment of pain and fever in children: modern views on the choice of a drug

Meditsinskiy sovet = Medical Council(17) (2023)

Irina N. Zakharova; I. V. Berezhnaya; Viktoria V. Pupykina; Anastasia D. Gostyukhina; N. F. Dubovets

22

Pharmacokinetic profile of metabolites by heart-cutting two-dimensional liquid chromatography: A focus on paracetamol analysis

Journal of Chromatography A 1745 (2025)

Ana Ballester-Caudet; S. Perea; Diego García‐Gómez; José Luis Pérez Pavón; Encarnación Rodríguez‐Gonzalo

23

Acetaminophen alters endogenous lipid signaling and attenuates pathological pain through a mechanism requiring diacylglycerol lipase, monoacylglycerol lipase and cannabinoid CB1 receptors in mice

Neuropharmacology 301 (2026)

Carlos Henrique Alves Jesus; Jonah L. Wirt; Taylor J. Woodward; Luana Assis Ferreira; Wenwen Du; John Hainline; Mirjam C. W. Huizenga; Lara Rems; Alexandros Makriyannis; Jenna A. Himelstein; Noah M. Brauer; Mario van der Stelt; Heather B. Bradshaw; Andrea G. Hohmann

24

The Ocular Penetration and Intraocular Pressure Lowering Effect of Topical Acetaminophen in the New Zealand White Rabbit

Journal of Ocular Pharmacology and Therapeutics 40(8) (2024)

Sean G. Anderson; David Meyer; David Meyer; Eric H. Decloedt

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26

Acetaminophen: for Its Mechanism of Analgesic Action in Vivo Using Molecular Docking

International Journal of Clinical & Experimental Dermatology 8(2) (2023)