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22 resultsUpdated October 20, 2026
2

Acetaminophen inhibits diacylglycerol lipase synthesis of 2-arachidonoyl glycerol: Implications for nociception

Cell Reports Medicine 6(6) (2025)

Michaela Dvorakova; Taryn Bosquez-Berger; Jenna Billingsley; Natalia Murataeva; Taylor Woodward; Emma Leishman; Anaëlle Zimmowitch; Anne Gibson; Jim Wager-Miller; Ruyi Cai; Shangxuan Cai; Tim Ware; Ku-Lung Hsu; Yulong Li; Heather Bradshaw; Ken Mackie; Alex Straiker

3

Pharmacokinetic profile of metabolites by heart-cutting two-dimensional liquid chromatography: A focus on paracetamol analysis

Journal of Chromatography A 1745 (2025)

Ana Ballester-Caudet; Simón Mariño Perea; Diego García-Gómez; José Luis Pérez Pavón; Encarnación Rodríguez-Gonzalo

4

The Molecular Basis of Cannabinoid Activity: Application to Therapeutics Design and Discovery for Cannabis Use Disorders

Cannabis Use Disorders (2018)

David R. Janero; V. Kiran Vemuri; Alexandros Makriyannis

5

Human sperm cells can form paracetamol metabolite AM404 that directly interferes with sperm calcium signalling and function through a CatSper-dependent mechanism

Human Reproduction 37(5) (2022)

A Rehfeld; H Frederiksen; R H Rasmussen; A David; J Chaker; B S Nielsen; J E Nielsen; A Juul; N E Skakkebæk; D M Kristensen

6

AM404, paracetamol metabolite, prevents prostaglandin synthesis in activated microglia by inhibiting COX activity

Journal of Neuroinflammation 14(1) (2017)

Soraya Wilke Saliba; Ariel R. Marcotegui; Ellen Fortwängler; Johannes Ditrich; Juan Carlos Perazzo; Eduardo Muñoz; Antônio Carlos Pinheiro de Oliveira; Bernd L. Fiebich

7

Paracetamol: Update on its Analgesic Mechanism of Action

Pain Relief - From Analgesics to Alternative Therapies (2017)

Christophe Mallet; Alain Eschalier; Laurence Daulhac

8

The nonsteroidal anti-inflammatory drugs and acetaminophen

Oxford Textbook of Pediatric Pain (2021)

Brian J. Anderson

10

Teratogenic effects induced by paracetamol, ciprofloxacin, and their mixture on Danio rerio embryos: Oxidative stress implications

Science of The Total Environment 806 (2022)

Jonathan Ricardo Rosas-Ramírez; José Manuel Orozco-Hernández; Gustavo Axel Elizalde-Velázquez; Demetrio Raldúa; Hariz Islas-Flores; Leobardo Manuel Gómez-Oliván

12

A Cannabinoid Receptor Type 1 (CB1R) Agonist Enhances the Developmental Neurotoxicity of Acetaminophen (Paracetamol)

Toxicological Sciences 166(1) (2018)

Gaëtan Philippot; Stefan Hallgren; Torsten Gordh; Anders Fredriksson; Robert Fredriksson; Henrik Viberg

13

Activation of the capsaicin-receptor TRPV1 by the acetaminophen metabolite N -arachidonoylaminophenol results in cytotoxicity

Life Sciences 194 (2018)

Thomas Stueber; Susanne Meyer; Annette Jangra; Axel Hage; Mirjam Eberhardt; Andreas Leffler

14

Transcriptomic signature, bioactivity and safety of a non-hepatotoxic analgesic generating AM404 in the midbrain PAG region

Scientific Reports 14(1) (2024)

Hernan A. Bazan; Surjyadipta Bhattacharjee; Madigan M. Reid; Bokkyoo Jun; Connor Polk; Madeleine Strain; Linsey A. St Pierre; Neehar Desai; Patrick W. Daly; Jessica A. Cucinello-Ragland; Scott Edwards; Javier Recio; Julio Alvarez-Builla; James J. Cai; Nicolas G. Bazan

15

The Ocular Penetration and Intraocular Pressure Lowering Effect of Topical Acetaminophen in the New Zealand White Rabbit

Journal of Ocular Pharmacology and Therapeutics 40(8) (2024)

Sean G. Anderson; David Meyer; Eric H. Decloedt

16

Systems pharmacology of hepatic metabolism in zebrafish larvae

Drug Discovery Today: Disease Models 22 (2016)

Rob C. van Wijk; Elke H.J. Krekels; Thomas Hankemeier; Herman P. Spaink; Piet H. van der Graaf

17

High-Dose Acetaminophen as a Treatment for Cancer

Livers 4(1) (2024)

Jeffrey Wu; Bradley Maller; Rujul Kaul; Andrea Galabow; Allyn Bryan; Alexander Neuwelt

18

Long-Term Paracetamol Treatment Impairs Cognitive Function and Brain-Derived Neurotrophic Factor in Adult Rat Brain

Scientia Pharmaceutica 91(1) (2023)

Laddawan Lalert; Nutnicha Tantarungsee; Tipthanan Chotipinit; Wilawan Ji-au; Anan Srikiatkhachorn; Supang Maneesri-le Grand

20

First evidence of the conversion of paracetamol to AM404 in human cerebrospinal fluid

Journal of Pain Research Volume 10 (2017)

Chhaya Sharma; Jamie H Long; Seema Shah; Junia Rahman; David Perrett; Samir Ayoub; Vivek Mehta

21

Gestational paracetamol exposure induces core behaviors of neurodevelopmental disorders in infant rats and modifies response to a cannabinoid agonist in females

Neurotoxicology and Teratology 99 (2023)

Rodrigo Moreno Klein; Vanessa Nishikawa Motomura; Juliana Diosti Debiasi; Estefânia Gastaldello Moreira

22

Paracetamol and ibuprofen in the treatment of pain and fever in children: modern views on the choice of a drug

Meditsinskiy sovet = Medical Council(17) (2023)

I. N. Zakharova; I. V. Berezhnaya; V. V. Pupykina; A. D. Gostyukhina; N. F. Dubovets