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e-ISSN 2383-1960
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Outline
The effect of selenase on the disease process of patients with septic shock admitted to the intensive care unit: A clinical trial in Tehran
Authors
Ebrahim Hazrati1, Mohammad Reza Rafii Rafii1, behzad kazemi haki2,*, Babak Shekarchi3, Seyed Javad Hosseini-Shokouh4
1Department of Anesthesiology, AJA University of Medical Sciences, Tehran, Iran, Andorra
2Bachelor of Anesthesiology, Tabriz University of Medical Sciences, Tabriz, Iran, Andorra
3Department of radiology, AJA University of Medical Sciences, Tehran, Iran, Andorra
4Department of Infectious Diseases and Tropical Medicine, AJA University of Medical Sciences, Tehran, Iran., Andorra
*Corresponding Author: Corresponding author: behzad kazemi haki, Bachelor of Anesthesiology, Tabriz University of Medical Sciences, Tabriz, Iran, Andorra Email: behzad_emt@yahoo.com
Published online:Apr 24, 2015
Article type:Research Article
Received:Jan 21, 2015
Accepted:Mar 24, 2015
How to Cite:Hazrati E, Rafii MRR, kazemi haki B, Shekarchi B, Hosseini-Shokouh SJ. The effect of selenase on the disease process of patients with septic shock admitted to the intensive care unit: A clinical trial in Tehran. Ann Mil Health Sci Res. 2015;13(1):e62678. doi:
Abstract
Materials and Methods: This double-blind clinical trial was done on 80 participants (40 case and 40 control) who were admitted to the ICU with septic shock. Every participant in the case group was administered 500 μg selenase twice daily for 10 days. In contrast, each participant of the control group was treated with placebo (normal saline). Data were collected by observation and recorded in a questionnaire. Chi-square and Student’s t-test were used for data analysis. Results: In this study 34 participants (42.5%) were men and 46 (57.5%) were women. The duration stay in the ICU in treatment group was less than in the observation group which was statistically significant (P = .01). There was also a significant difference regarding the frequency of morbidity and mortality rates between the two groups (P = .03 and P = .02, respectively). Conclusion: Selenium at a dosage of 500 μg (twice daily) is effective in those who have suffered from septic shock. Still, more studies are needed to determine the best dosage and administration method of this drug.
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Copyright
© 2015, Annals of Military and Health Sciences Research. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.
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